INT214844

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP10) peptidase activity (CASP10) plasma membrane (CASP10)
CASP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 17.80 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 36 99.32 Very High Very High Very High
Apoptosis 143 98.76 Very High Very High Very High
Opportunistic Infections 1 91.20 High High
Fever 3 87.48 High High
Shigella Infection 3 86.08 High High
Repression 4 59.44 Quite High
Viral Infection 2 59.28 Quite High
Venezuelan Equine Encephalomyelitis 9 50.00 Quite Low
Togavirus Infection 2 47.60 Quite Low
INFLAMMATION 5 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.
Positive_regulation (increased) of Gene_expression (levels) of caspase 10
1) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.85 Pain Relevance 0
Caspase-10 is activated in the extrinsic pathway of apoptosis, and etoposide, a chemotherapeutic agent and cytotoxic drug, induces CASP10 expression in a p53-dependent manner [80,81].
Positive_regulation (induces) of Gene_expression (expression) of CASP10 associated with apoptosis
2) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.29 Pain Relevance 0

General Comments

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