INT214845

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP10) peptidase activity (CASP10) plasma membrane (CASP10)
CASP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 16.52 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 475 98.84 Very High Very High Very High
Infection 88 98.04 Very High Very High Very High
Opportunistic Infections 1 91.20 High High
Shigella Infection 9 91.00 High High
Reprotox - General 1 10 89.40 High High
Fever 3 86.20 High High
Colon Cancer 43 84.72 Quite High
Repression 15 75.44 Quite High
Viral Infection 2 58.00 Quite High
Venezuelan Equine Encephalomyelitis 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.
Positive_regulation (increased) of caspase 10
1) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.84 Pain Relevance 0
Caspase-10 is activated in the extrinsic pathway of apoptosis, and etoposide, a chemotherapeutic agent and cytotoxic drug, induces CASP10 expression in a p53-dependent manner [80,81].
Positive_regulation (activated) of Caspase-10 associated with apoptosis
2) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.25 Pain Relevance 0
In fact, caspase-10 activation can be inhibited if cytochrome c release is inhibited.
Positive_regulation (activation) of caspase-10
3) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.34 Pain Relevance 0
In addition, caspase-10 is activated after cytochrome c release to amplify caspase-9 and caspase-3 activation in the presence of etoposide.
Positive_regulation (activated) of caspase-10
4) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.29 Pain Relevance 0
Our results demonstrate near 100% agreement between microarray and qRT-PCR results with the lone exception being PDCD6 (Figure 2B), and immunoblotting revealed that up-regulation of Caspase 10 and BTG1 mRNAs was linked with protein up-regulation (compare Figures 2A and 2C).
Positive_regulation (regulation) of Caspase 10
5) Confidence 0.18 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.25 Pain Relevance 0

General Comments

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