INT21487

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 29.81
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
HCC (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 100.00 Very High Very High Very High
Inflammation 52 97.00 Very High Very High Very High
imagery 112 95.24 Very High Very High Very High
abdominal pain 3 93.88 High High
cINOD 45 92.92 High High
Pain 6 89.44 High High
fibrosis 135 89.28 High High
alcohol 8 87.04 High High
palliative 6 70.00 Quite High
Sicca syndrome 1 64.64 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 983 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 208 100.00 Very High Very High Very High
Cirrhosis 201 100.00 Very High Very High Very High
Carcinoma 26 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Metastasis 68 99.68 Very High Very High Very High
Thyroid Neoplasm 161 99.54 Very High Very High Very High
Hepatitis C Virus Infection 283 98.92 Very High Very High Very High
Hepatitis B Virus Infection 101 98.86 Very High Very High Very High
Cancer 250 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although further in vivo studies are required in animal models to confirm these findings and define optimal doses for future clinical trials in human subjects, these findings provide a rationale for the use of COX-2 inhibitors as HCC chemoprevention.
Negative_regulation (inhibitors) of HCC associated with hepatocellular cancer and cox-2 inhibitor
1) Confidence 0.49 Published 2002 Journal J. Lab. Clin. Med. Section Abstract Doc Link 12024111 Disease Relevance 1.00 Pain Relevance 0.21
There is growing evidence that HCC may be prevented with strategies aimed at preventing or treating viral hepatitis.
Negative_regulation (prevented) of HCC associated with hepatocellular cancer and hepatitis virus infection
2) Confidence 0.37 Published 2002 Journal J Vasc Interv Radiol Section Abstract Doc Link 12354833 Disease Relevance 0.95 Pain Relevance 0.14
Expansion of criteria for transplantation is being considered and downstaging HCC to within transplant criteria is being used in some centers using locoregional therapy.
Negative_regulation (downstaging) of HCC associated with hepatocellular cancer
3) Confidence 0.37 Published 2009 Journal Minerva Med. Section Abstract Doc Link 19277004 Disease Relevance 1.23 Pain Relevance 0.07
The average time to develop HCC after initial exposure to HCV is about 28 years and usually about 8–10 years after the development of liver cirrhosis.
Negative_regulation (develop) of HCC in liver associated with cirrhosis, hepatocellular cancer and hepatitis c virus infection
4) Confidence 0.14 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 2.73 Pain Relevance 0.07
In summary, APC gene mutations do not seem to play an important role in the inactivation of APC in HCC.
Negative_regulation (inactivation) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
5) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
These findings suggest that quantitative epigenetic changes are probably of clinical significance in hepatocarcinogenesis, but further post-transcriptional mechanisms must also be responsible for inactivation of the APC gene in HCC.
Negative_regulation (inactivation) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
6) Confidence 0.12 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0.05
Quantifying the proportion of HCC attributable to aflatoxin exposure, to HBV, and to the interaction of aflatoxin exposure and HBV will help identify the best public health strategies to reduce HCC, including the benefits and limits of widespread HBV vaccination.
Negative_regulation (reduce) of HCC associated with hepatocellular cancer and hepatitis b virus infection
7) Confidence 0.10 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764136 Disease Relevance 1.42 Pain Relevance 0
Interestingly, coffee consumption appears to reduce the HCC risk (Bravi et al 2007).
Spec (appears) Negative_regulation (reduce) of HCC associated with hepatocellular cancer
8) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 2.21 Pain Relevance 0.08
Radioiodine ablation has been shown to be ineffective in patients with MTC and is only minimally effective in HCC; hence, it is not commonly used in these patients.
Negative_regulation (effective) of HCC associated with thyroid neoplasm and carcinoma
9) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.24 Pain Relevance 0.12
Thus, HCC prevention might represent the best opportunity to reduce the worldwide burden of disease.
Negative_regulation (prevention) of HCC associated with hepatocellular cancer and disease
10) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 2.15 Pain Relevance 0.05
HCC epidemiology
Negative_regulation (epidemiology) of HCC
11) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.70 Pain Relevance 0
After treatment, the biopsy specimens showed total necrosis of HCC.
Negative_regulation (necrosis) of HCC associated with necrosis
12) Confidence 0.03 Published 1990 Journal Hepatogastroenterology Section Abstract Doc Link 2174823 Disease Relevance 1.20 Pain Relevance 0.09
Since the non-HCC patients were also elderly, some other host factor in addition to oxidative damage, must be delaying HCC in this group.
Negative_regulation (delaying) of HCC associated with hepatocellular cancer
13) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.58 Pain Relevance 0
Continuously low ALT, biochemical or partial response to initial IFN therapy and IFN re-treatment may have prevented HCC, in these patients (33~35).
Negative_regulation (prevented) of HCC associated with hepatocellular cancer
14) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.34 Pain Relevance 0.13
As for the patient who developed HCC, irrespective of IFN re-treatment, it may be assumed that since the patient developed HCC within 18 months of IFN treatment, perhaps there was a pre-existing HCC, prior to IFN therapy for which HCC could not be prevented even with additional IFN.
Negative_regulation (prevented) of HCC associated with hepatocellular cancer
15) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.47 Pain Relevance 0
When HCC and non HCC patients were compared, none of the BR patients developed HCC.
Negative_regulation (developed) of HCC associated with hepatocellular cancer
16) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.77 Pain Relevance 0.19
80 IU/l on most occasions seemed to have contributed to HCC prevention until now.
Negative_regulation (prevention) of HCC associated with hepatocellular cancer
17) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.43 Pain Relevance 0.09
Though not significant, it was found that of the 13 patients who received supplementary Vitamin E treatment, only 2 developed HCC.
Negative_regulation (developed) of HCC associated with hepatocellular cancer
18) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.14 Pain Relevance 0.14
During the 6 year follow-up period, 7 patients developed HCC.
Negative_regulation (developed) of HCC associated with hepatocellular cancer
19) Confidence 0.02 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.65 Pain Relevance 0.38
Therefore, antiviral therapy aims at the prevention of cirrhosis, hepatic decompensation, and HCC [8].
Negative_regulation (prevention) of HCC associated with cirrhosis and hepatocellular cancer
20) Confidence 0.01 Published 2010 Journal Curr Hepat Rep Section Body Doc Link PMC2945466 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

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