INT21488

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Context Info
Confidence 0.20
First Reported 1987
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp6) cytoplasm (Fabp6)
Anatomy Link Frequency
lobe 2
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 4 100.00 Very High Very High Very High
noradrenaline 5 99.96 Very High Very High Very High
antagonist 2 94.88 High High
tetrodotoxin 2 94.24 High High
Dopamine 1 81.96 Quite High
adenocard 2 78.76 Quite High
agonist 1 33.32 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 12 100.00 Very High Very High Very High
Sprains And Strains 2 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical-field stimulation (EFS; 0.1 ms, 20 V, 0.2 Hz) induced an enhanced excitatory junction potential (EJP) in SHR but not in WKY (16.0+/-0.6 mV vs. 12.2+/-0.5 mV) which was abolished by TTX (1 microM), suramin (30 microM) and alpha,beta-meATP (30 microM).
Negative_regulation (abolished) of Neg (not) Positive_regulation (induced) of SHR associated with hypertension
1) Confidence 0.20 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12382071 Disease Relevance 0.54 Pain Relevance 0.13
The results suggest that activation of prejunctional PGE2 receptors in kidneys of SHR and WKY inhibits noradrenaline release.
Negative_regulation (inhibits) of Positive_regulation (activation) of SHR associated with noradrenaline
2) Confidence 0.14 Published 1990 Journal J. Hypertens. Section Abstract Doc Link 2174941 Disease Relevance 0.20 Pain Relevance 0.31
Administration of yohimbine (1 mg/kg) completely blocked the clonidine-induced increase of neurointermediate lobe beta-endorphinlike immunoreactivity in SHR, while prazosin (1 mg/kg) had no effect.
Negative_regulation (blocked) of Positive_regulation (increase) of SHR in lobe associated with clonidine
3) Confidence 0.01 Published 1987 Journal Hypertension Section Abstract Doc Link 3034777 Disease Relevance 0.15 Pain Relevance 0.35

General Comments

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