INT214891

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN1A) cell morphogenesis (HGF) cytoplasm (CDKN1A)
cytosol (CDKN1A) extracellular space (HGF) mitosis (HGF)
Anatomy Link Frequency
HGF 3
HGF (Homo sapiens)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 43.36 Quite Low
fibrosis 3 10.00 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 108 99.12 Very High Very High Very High
Cyst 63 96.12 Very High Very High Very High
Disease 78 93.40 High High
Apoptosis 96 80.96 Quite High
Targeted Disruption 12 70.16 Quite High
Cancer 30 51.64 Quite High
Body Weight 6 46.88 Quite Low
Cystic Kidney Diseases 18 34.48 Quite Low
Chronic Renal Failure 9 32.84 Quite Low
Fibrosis 3 10.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HGF, which induces transition from a cystic to a tubular phenotype, induces p21
HGF Positive_regulation (induces) of p21 in HGF
1) Confidence 0.25 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.22 Pain Relevance 0
We have also begun to evaluate whether p21 is pathogenic in ADPKD, by showing that hepatocyte growth factor (HGF), which induces transition from a cystic to a tubular phenotype in vitro, increases p21 levels, and that levels of p21 correlate inversely with proliferation of RTE cells.
HGF Positive_regulation (increases) of p21 in HGF associated with polycystic kidney disease
2) Confidence 0.17 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.66 Pain Relevance 0
Interestingly, while not evaluated in relation to a cystic phenotype, p21 has been shown to be induced by HGF in several cell lines [16], consistent with our hypothesis that p21 mediates the tubulogenic, not the cystic, phenotype.
HGF Positive_regulation (induced) of p21 in HGF
3) Confidence 0.17 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.27 Pain Relevance 0

General Comments

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