INT2149

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 7
Speculated 3
Reported most in Abstract
Documents 181
Total Number 194
Disease Relevance 24.80
Pain Relevance 85.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 48
neurons 11
supraoptic nucleus 10
PVN 8
blood 5
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 414 100.00 Very High Very High Very High
agonist 372 100.00 Very High Very High Very High
Spinal cord 163 100.00 Very High Very High Very High
Enkephalin 75 100.00 Very High Very High Very High
Dynorphin 53 100.00 Very High Very High Very High
Kappa opioid receptor 20 100.00 Very High Very High Very High
nociceptor 5 100.00 Very High Very High Very High
antagonist 626 99.98 Very High Very High Very High
fluoxetine 139 99.98 Very High Very High Very High
Antinociceptive 118 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 199 100.00 Very High Very High Very High
Pressure And Volume Under Development 15 100.00 Very High Very High Very High
Dysmenorrhea 17 99.98 Very High Very High Very High
Congenital Anomalies 15 99.96 Very High Very High Very High
Anxiety Disorder 124 99.84 Very High Very High Very High
Hyponatremia 73 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 34 99.28 Very High Very High Very High
Infection 9 99.10 Very High Very High Very High
Weight Loss 12 99.08 Very High Very High Very High
Urological Neuroanatomy 51 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These rats exhibited an increase in blood levels of oxytocin during parturition similar to those of shamoperated control rats, but delivery took longer and there was a higher percentage of still-births.
Positive_regulation (increase) of oxytocin in blood
1) Confidence 0.70 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3711758 Disease Relevance 0.06 Pain Relevance 0
Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anaesthetized rats.
Positive_regulation (Increased) of oxytocin in vagal nerves associated with nociceptor
2) Confidence 0.70 Published 1988 Journal Acta Physiol. Scand. Section Title Doc Link 3223304 Disease Relevance 0.15 Pain Relevance 0.10
This injection resulted in significantly elevated plasma oxytocin levels and increased discharge activity of putative oxytocin cells in the supraoptic nucleus.
Positive_regulation (resulted) of oxytocin in supraoptic nucleus
3) Confidence 0.69 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3399134 Disease Relevance 0 Pain Relevance 0.15
Subsequent injection of naloxone (1 mg/kg) i.v. resulted in a similarly large increase in plasma oxytocin, but did not affect the discharge activity of putative oxytocin neurones.
Positive_regulation (increase) of oxytocin in plasma associated with narcan
4) Confidence 0.69 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3399134 Disease Relevance 0 Pain Relevance 0.17
On days 15, 18 and 21 of pregnancy but not in non-pregnant, early pregnant or post-partum rats, the opioid antagonist naloxone caused a significant increase in plasma oxytocin compared to vehicle injection, indicating activation of an endogenous opioid restraint over oxytocin secretion.
Positive_regulation (increase) of oxytocin in plasma associated with antagonist, endogenous opioid, narcan and opioid
5) Confidence 0.69 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8100468 Disease Relevance 0 Pain Relevance 0.63
The initial decrease in plasma oxytocin reversed, and 4 h after injection of bremazocine a 20-fold increase in the oxytocin level was seen.
Positive_regulation (increase) of oxytocin in plasma
6) Confidence 0.69 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (accumulation) of OXT in hypothalamus associated with neuropeptide
7) Confidence 0.68 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.23
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (accumulation) of oxytocin in hypothalamus associated with neuropeptide
8) Confidence 0.68 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.22
Electrical acupuncture of "Zusanli" points (St. 36) 30 min increased the AVP, not OXT, L-Ek, beta-Ep and DynA(1-13) concentrations in PVH tissue using micropunch and radioimmunoassay, which showed a negative relationship between the pain threshold and AVP concentrations in PVH tissue.
Neg (not) Positive_regulation (increased) of OXT in PVH associated with pain threshold and acupuncture
9) Confidence 0.68 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.09 Pain Relevance 0.66
Naloxone administered 10 min before the second stimulus increased basal plasma oxytocin concentration in virgin and pregnant rats and increased the oxytocin secretory response to 25 Hz AV3V stimulation in virgin but not pregnant rats, and the response was significantly greater in virgin rats.
Positive_regulation (increased) of oxytocin in plasma associated with narcan
10) Confidence 0.68 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7920592 Disease Relevance 0 Pain Relevance 0.50
In rats in which the pituitary gland was not removed after stalk section, the i.v. injection of naloxone hydrochloride (5 mg/kg) resulted in a large and sustained increase in the concentration of oxytocin in both portal and peripheral plasma in control and morphine-dependent rats.
Positive_regulation (increase) of oxytocin in pituitary gland associated with narcan and morphine
11) Confidence 0.67 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2299273 Disease Relevance 0.07 Pain Relevance 1.25
In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC.
Positive_regulation (increased) of oxytocin in SON associated with locus ceruleus, narcan and morphine
12) Confidence 0.67 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.10 Pain Relevance 0.88
Oxytocin levels increase in blood and CSF after various kinds of non-noxious sensory stimulation such as touch, light pressure and warm temperature in both female and male rats.
Positive_regulation (increase) of Oxytocin in blood
13) Confidence 0.67 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.30 Pain Relevance 0.34
These data indicate that pharmacological amounts of oxytocin produce antinociception, that occurs through the activation of oxytocin receptors; endogenous opioid systems seem to be involved altogether.
Positive_regulation (activation) of oxytocin associated with antinociception and endogenous opioid
14) Confidence 0.66 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8474630 Disease Relevance 0.15 Pain Relevance 0.65
Thus, at term pregnancy, uterine contractions activate both oxytocin and vasopressin neurons in the SON, and this activation involves a noradrenergic pathway.
Positive_regulation (activate) of oxytocin in uterine associated with dismenorea
15) Confidence 0.66 Published 2001 Journal Endocrinology Section Abstract Doc Link 11159834 Disease Relevance 0.10 Pain Relevance 0.23
We tested the hypotheses that contractions of the uterus before pup delivery activate oxytocin neurons, and that they do so via a noradrenergic projection.
Positive_regulation (activate) of oxytocin in neurons
16) Confidence 0.66 Published 2001 Journal Endocrinology Section Abstract Doc Link 11159834 Disease Relevance 0 Pain Relevance 0.03
Pretreated rats (naloxone, saline or nor-BNI, Day 1) received an additional acute nor-BNI injection (Day 4) which increased plasma oxytocin concentration in the three groups.
Positive_regulation (increased) of plasma oxytocin in plasma associated with narcan
17) Confidence 0.65 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9776384 Disease Relevance 0 Pain Relevance 0.76
ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl).
Positive_regulation (induced) of OXT in plasma
18) Confidence 0.61 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.15 Pain Relevance 0.17
In urethane-anaesthetized ovariectomized rats, injection of porcine relaxin (7.5 and 15 micrograms/kg, i.v.) caused a sustained increase in circulating plasma oxytocin and vasopressin concentrations; 10 micrograms relaxin/rat i.v. produced a smaller but significant increase in plasma oxytocin concentration in conscious ovariectomized rats.
Positive_regulation (increase) of oxytocin in plasma
19) Confidence 0.61 Published 1992 Journal J. Endocrinol. Section Abstract Doc Link 1737954 Disease Relevance 0 Pain Relevance 0
Also, this diet inhibited the magnitude of 8-OH-DPAT-induced increase in plasma levels of ACTH and oxytocin but did not impair the ability of fluoxetine to desensitize the 5-HT1A receptor-mediated increase in plasma hormones.
Positive_regulation (increase) of oxytocin in plasma associated with fluoxetine
20) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14604841 Disease Relevance 0.27 Pain Relevance 0.70

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