INT214917

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pkd1, CDKN1A) nucleoplasm (CDKN1A) Golgi apparatus (Pkd1)
cilium (Pkd1) cytoplasm (CDKN1A) cytosol (CDKN1A)
Pkd1 (Rattus norvegicus)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 36 100.00 Very High Very High Very High
Disease 26 90.16 High High
Apoptosis 32 85.76 High High
Cancer 10 74.92 Quite High
Cyst 21 64.76 Quite High
Disease Progression 4 62.16 Quite High
Retinoblastoma 3 35.04 Quite Low
Chronic Renal Failure 3 27.16 Quite Low
Renal Disease 3 25.60 Quite Low
Cystic Kidney Diseases 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have built on the observation that polycystin-1, the gene product of PKD1 which is mutated in 85% of ADPKD cases, induces the cyclin kinase inhibitor p21[9].
polycystin-1 Positive_regulation (induces) of Negative_regulation (inhibitor) of p21 associated with polycystic kidney disease
1) Confidence 0.37 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.46 Pain Relevance 0

General Comments

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