INT214918

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gtf3a, CDKN1A) nucleoplasm (CDKN1A) intracellular (Gtf3a)
DNA binding (Gtf3a) cytoplasm (CDKN1A) cytosol (CDKN1A)
Anatomy Link Frequency
HGF 1
Gtf3a (Rattus norvegicus)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 43.36 Quite Low
fibrosis 1 10.00 Low Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 36 99.28 Very High Very High Very High
Disease 26 93.72 High High
Apoptosis 32 80.96 Quite High
Targeted Disruption 4 70.48 Quite High
Cancer 10 51.96 Quite High
Cyst 21 49.80 Quite Low
Fibrosis 1 10.00 Low Low
Cystic Kidney Diseases 6 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Retinoblastoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also begun to evaluate whether p21 is pathogenic in ADPKD, by showing that hepatocyte growth factor (HGF), which induces transition from a cystic to a tubular phenotype in vitro, increases p21 levels, and that levels of p21 correlate inversely with proliferation of RTE cells.
factor Positive_regulation (increases) of p21 in HGF associated with polycystic kidney disease
1) Confidence 0.01 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.66 Pain Relevance 0

General Comments

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