INT214919

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pkd1, CDKN1A) nucleoplasm (CDKN1A) Golgi apparatus (Pkd1)
cilium (Pkd1) cytoplasm (CDKN1A) cytosol (CDKN1A)
Pkd1 (Rattus norvegicus)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 108 100.00 Very High Very High Very High
Apoptosis 96 98.80 Very High Very High Very High
Disease 78 97.78 Very High Very High Very High
Renal Disease 9 85.12 High High
Cancer 30 74.92 Quite High
Disease Progression 12 74.64 Quite High
Targeted Disruption 12 72.08 Quite High
Cystic Kidney Diseases 18 64.80 Quite High
Cyst 63 64.76 Quite High
Retinoblastoma 9 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present findings that ADPKD, which is characterized by increased RTE cell growth, may in fact be a disease which results from diminished p21 expression in affected tissues are consistent with recent data showing that polycystin-1 induces p21 [9] and causes resistance to apoptosis [23].
polycystin-1 Positive_regulation (induces) of p21 associated with polycystic kidney disease, apoptosis and disease
1) Confidence 0.51 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.76 Pain Relevance 0
In this study, we have built on the observation that polycystin-1, the gene product of PKD1 which is mutated in 85% of ADPKD cases, induces the cyclin kinase inhibitor p21[9].
polycystin-1 Positive_regulation (induces) of p21 associated with polycystic kidney disease
2) Confidence 0.51 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.46 Pain Relevance 0
While p21 has been shown to be induced by polycystin-1[9], there are as yet no studies demonstrating that a lack of p21, as would be expected with mutant PKD1, occurs in vivo in humans or in those animal models not characterized by targeted gene disruption.
polycystin-1 Positive_regulation (induced) of p21
3) Confidence 0.30 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.38 Pain Relevance 0

General Comments

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