INT21492

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.36
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn1a) transmembrane transport (Scn1a)
Anatomy Link Frequency
brain 1
blood cell 1
Scn1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 20 100.00 Very High Very High Very High
agonist 1 99.08 Very High Very High Very High
MU agonist 1 96.80 Very High Very High Very High
adenocard 2 94.48 High High
opioid receptor 1 91.60 High High
Nav1.1 1 77.92 Quite High
sodium channel 1 77.64 Quite High
Neurotransmitter 1 76.32 Quite High
Opioid 1 56.64 Quite High
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Headache 11 100.00 Very High Very High Very High
Disease 1 100.00 Very High Very High Very High
Epilepsy 6 99.26 Very High Very High Very High
Migraine With Aura 9 95.92 Very High Very High Very High
Myoclonic Epilepsies 2 80.56 Quite High
Syndrome 1 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar experiments conducted with guinea pig brain aggregate cultures indicated that the kappa selective agonist U50,488 decreased the amount of the membrane bound alpha i protein subunit by 56%.
alpha i protein subunit Binding (bound) of in brain associated with agonist
1) Confidence 0.37 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 2174976 Disease Relevance 0 Pain Relevance 0.25
In one of these families, direct sequencing of blood cell DNA was not sufficient to the SCN1A mutation in the transmitting asymptomatic parent who was mosaic for the mutation.
SCN1A Binding (sufficient) of in blood cell
2) Confidence 0.37 Published 2006 Journal Hum. Mutat. Section Abstract Doc Link 16541393 Disease Relevance 0.16 Pain Relevance 0.12
Of the many epilepsy genes that have been discovered, an association with migraine has been reported only for SCN1A.
SCN1A Binding (association) of associated with epilepsy and migraine
3) Confidence 0.25 Published 2008 Journal Expert Rev Neurother Section Abstract Doc Link 18759542 Disease Relevance 1.28 Pain Relevance 0.83
Here, we report the genetic analysis of four families and one sporadic case with hemiplegic migraine (HM) in whom we searched for mutations in the three genes associated with the disease CACNA1A, ATP1A2 and SCN1A.
SCN1A Binding (associated) of associated with migraine and disease
4) Confidence 0.08 Published 2007 Journal Clin. Genet. Section Abstract Doc Link 17877748 Disease Relevance 0.92 Pain Relevance 0.84

General Comments

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