INT214926

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.93
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (INPP5E) plasma membrane (INPP5E) cytoskeleton (INPP5E)
cilium (INPP5E) biological_process (INPP5E) lipid metabolic process (INPP5E)
INPP5E (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 71.28 Quite High
Inflammation 14 57.96 Quite High
Neurobehavioral 13 50.00 Quite Low
IPN 2 13.20 Low Low
Bile 42 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Visceral pain 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastroesophageal Reflux Disease 140 99.84 Very High Very High Very High
Anxiety Disorder 2 99.84 Very High Very High Very High
Dyspepsia 26 95.32 Very High Very High Very High
Disease 31 94.96 High High
Acid Reflux 50 92.84 High High
Mental Disorders 11 85.44 High High
Esophageal Disease 25 81.00 Quite High
Duodenal Ulcer 1 80.08 Quite High
Schizophrenia 10 79.04 Quite High
Peptic Ulcer 2 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, a precise definition of PPI failure and PPI success is needed.
Negative_regulation (failure) of PPI
1) Confidence 0.03 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.44 Pain Relevance 0
Proton pump inhibitor (PPI) therapy is effective for acid-related symptoms.
Negative_regulation (inhibitor) of PPI
2) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2170952 Disease Relevance 1.93 Pain Relevance 0.09
Gastro-esophageal reflux disease (GERD) is a chronic disorder and remains the most common gastrointestinal-related diagnosis given on office visits.1 The introduction of proton pump inhibitors (PPIs) has improved the esophageal mucosal healing and symptom control, however reports on PPI therapeutic failure in GERD patients have increased during the last years.
Negative_regulation (failure) of PPI associated with gastroesophageal reflux disease and disease
3) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.49 Pain Relevance 0
In addition, a precise definition of PPI failure and PPI success is needed.
Negative_regulation (definition) of PPI
4) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.44 Pain Relevance 0
PPI is the reduction in startle response elicited by a strong sensory stimulus that occurs when the latter is preceded by a weaker signal [85].
Negative_regulation (reduction) of PPI associated with anxiety disorder
5) Confidence 0.02 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2872755 Disease Relevance 0.62 Pain Relevance 0
This is necessary in order to infer the phenotypic effects caused by inhibition of the PPI in the cell.
Negative_regulation (inhibition) of PPI
6) Confidence 0.02 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2045083 Disease Relevance 0 Pain Relevance 0
In order to inhibit a PPI by SDCs, one or both of the two interacting proteins should have a pocket on protein surface to which SDCs can bind.
Negative_regulation (inhibit) of PPI
7) Confidence 0.02 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2045083 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox