INT214945

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.65
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu3) plasma membrane (Neu3) carbohydrate metabolic process (Neu3)
Anatomy Link Frequency
neurons 3
eukaryotic cells 1
Neu3 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 2 94.68 High High
Thalamus 8 93.84 High High
tetrodotoxin 18 88.00 High High
Central nervous system 6 74.68 Quite High
Spinal cord 2 70.80 Quite High
Action potential 10 66.44 Quite High
Kinase C 1 54.68 Quite High
agonist 103 50.00 Quite Low
sodium channel 2 49.12 Quite Low
antagonist 60 48.56 Quite Low
Disease Link Frequency Relevance Heat
Congenital Structural Myopathies 17 99.70 Very High Very High Very High
Frailty 2 95.04 Very High Very High Very High
Muscle Weakness 4 94.56 High High
Tremor 232 89.24 High High
Insulin Resistance 25 89.04 High High
Syndrome 8 86.20 High High
Paralysis 1 56.88 Quite High
Disorder Of Lipid Metabolism 6 52.52 Quite High
Targeted Disruption 40 45.56 Quite Low
INFLAMMATION 3 44.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cytoskeletal proteins not only contribute to the structural organization of cytoplasm but also play important roles in regulating the topography of the plasma membrane and trafficking and in modulating the localization of lipid raft proteins in eukaryotic cells [47,48].
Regulation (regulating) of membrane in eukaryotic cells
1) Confidence 0.01 Published 2007 Journal Proteome Sci Section Body Doc Link PMC2045652 Disease Relevance 0 Pain Relevance 0
Membrane active sterols are important for regulation of membrane fluidity and in addition, some sterols are responsible for promoting liquid-ordered phase formation.
Regulation (regulation) of membrane
2) Confidence 0.00 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0 Pain Relevance 0
Nevertheless, substitution of cholesterol by desmosterol does not affect membrane integrity or caveolar invagination and caveolar ligand uptake is only moderately inhibited in these cells [19].
Neg (not) Regulation (affect) of membrane
3) Confidence 0.00 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0.05 Pain Relevance 0
This sterol was studied in model membranes and was found to differ from cholesterol in a number of important parameters, for example, 7-ketocholesterol is less effective in forming ordered lipid domains, and was shown to differentially modulate membrane properties involved in protein-membrane association and function [44].
Regulation (modulate) of membrane
4) Confidence 0.00 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0 Pain Relevance 0
Recently, mutations in the amphyphisin 2/Bin1 gene in patients with an autosomal recessive form of CNM were shown to alter its membrane tubulation properties and interaction with dynamin 2 (6).
Regulation (alter) of membrane associated with congenital structural myopathies
5) Confidence 0.00 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.43 Pain Relevance 0
Responsive neurons were distinguished from non-responding neurons based on the criterion that the change in membrane potential (?
Regulation (change) of membrane in neurons
6) Confidence 0.00 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0 Pain Relevance 0.18
In POMC neurons unaffected by application of 5-HT (Fig. 7C), there was no significant change in either resting membrane potential (?
Neg (no) Regulation (change) of membrane in neurons
7) Confidence 0.00 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0 Pain Relevance 0.03
In RIPCre neurons where electrical activity was unaffected by application of 5-HT (Fig. 1C), there was no significant change in either resting membrane potential (?
Neg (no) Regulation (change) of membrane in neurons
8) Confidence 0.00 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0 Pain Relevance 0.08
The FA saturation degree and FA chain length as well as the relative abundance of individual FA have been described to affect membrane composition and rigidity/fluidity [28].
Regulation (affect) of membrane
9) Confidence 0.00 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.16 Pain Relevance 0.03
Two of the possible effects of this mutation could be directly related to the regulation of membrane excitability.
Regulation (regulation) of membrane
10) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.81 Pain Relevance 0.12
Likewise, there are a number of intracellular modulators regulating Ih including intracellular levels of calcium, cAMP, and pH [15,16] that could affect membrane excitability.
Regulation (affect) of membrane
11) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.20 Pain Relevance 0.07

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