INT214950

Context Info Confidence 0.32 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.79 Pain Relevance 0.39

Anatomy Link Frequency endothelial cell 2 Gbp1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 9 98.92 Inflammation 9 98.52 Glutamate receptor 1 97.36 Inflammatory response 3 94.76 Neurotransmitter 2 84.68 Limbic system 1 27.52 Opioid 1 19.52 interstitial cystitis 2 5.00 sodium channel 1 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 13 98.52 Mycobacterial Infection 7 85.92 Adhesions 2 52.08 Infection 11 5.00 Bladder Cancer 10 5.00 Cancer 10 5.00 Brain Disease 3 5.00 Interstitial Cystitis 2 5.00 Disease 2 5.00 Cystitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The finding that GBP-1 expression is inhibited by potent activators of endothelial cell proliferation such as VEGF and bFGF [52], leads to the hypothesis that GTPases are in the cross-road of inflammation and vascular proliferation.

Negative_regulation (inhibited) of Gene_expression (expression) of GBP-1 in endothelial cell associated with inflammation

1) Confidence 0.32 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.74 Pain Relevance 0.27

Relatively large numbers of guanine nucleotide-binding protein (G protein) isoforms and Ras subfamily of GTPases were identified; G(s)?

Negative_regulation (numbers) of Gene_expression (isoforms) of guanine nucleotide-binding protein

2) Confidence 0.16 Published 2007 Journal Proteome Sci Section Body Doc Link PMC2045652 Disease Relevance 0.05 Pain Relevance 0.12

General Comments

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