INT214974

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
CFPAC-1 3
filament 2
AsPC-1 1
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 15 83.84 Quite High
imagery 3 83.20 Quite High
cocaine 2 75.00 Quite High
potassium channel 6 55.36 Quite High
opioid receptor 4 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 27 99.60 Very High Very High Very High
Cancer 170 98.00 Very High Very High Very High
Apoptosis 114 87.12 High High
Pancreatic Cancer 81 81.08 Quite High
Stress 4 66.76 Quite High
Immunotherapy Of Cancer 6 62.40 Quite High
Starvation 3 47.64 Quite Low
Hypoxia 3 46.80 Quite Low
Malignant Neoplastic Disease 3 40.88 Quite Low
Toxicity 30 37.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that murine (Panc-02) and human (AsPC-1, CFPAC-1, and Panc-1) pancreatic adenocarcinoma cell lines display increased expression of the sigma-2 receptor [13].
Positive_regulation (increased) of Gene_expression (expression) of sigma-2 receptor in CFPAC-1 associated with adenocarcinoma
1) Confidence 0.52 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.51 Pain Relevance 0.06
Several groups of investigators have shown that sigma-2 receptor expression is markedly increased across diverse malignancies.
Positive_regulation (increased) of Gene_expression (expression) of sigma-2 receptor
2) Confidence 0.52 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.91 Pain Relevance 0.04
Following direct actin filament stabilization with phalloidin a doubling of the level of talin in the FAC was observed, while the sigma-1 receptor levels in the FAC increased more than 6 fold (Fig. 4.).
Positive_regulation (increased) of Gene_expression (levels) of sigma-1 receptor in filament
3) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0 Pain Relevance 0.22
We have previously reported that murine (Panc-02) and human (AsPC-1, CFPAC-1, and Panc-1) pancreatic adenocarcinoma cell lines display increased expression of the sigma-2 receptor [13].
Positive_regulation (increased) of in AsPC-1 Gene_expression (expression) of sigma-2 receptor in CFPAC-1 associated with adenocarcinoma
4) Confidence 0.18 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.51 Pain Relevance 0.06

General Comments

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