INT214975

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.70
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
plasma 2
fibroblasts 1
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 14 77.92 Quite High
fortral 6 53.84 Quite High
Inflammatory mediators 8 39.48 Quite Low
addiction 3 39.20 Quite Low
potassium channel 12 35.48 Quite Low
Inflammation 16 30.64 Quite Low
cytokine 7 24.00 Low Low
Dopamine 20 5.00 Very Low Very Low Very Low
ketamine 15 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 22 97.24 Very High Very High Very High
Stress 55 80.20 Quite High
Hypokalemic Periodic Paralysis 29 78.48 Quite High
Injury 9 78.16 Quite High
Congenital Generalized Lipodystrophy 22 75.00 Quite High
Syndrome 18 75.00 Quite High
Arrhythmia Under Development 9 75.00 Quite High
Osteoporosis 14 74.48 Quite High
Hypertrophic Pyloric Stenosis 14 70.68 Quite High
Hypertrophy 14 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patient fibroblasts, however, caveolin-1 failed to localize toward the cell surface and electron microscopy revealed reduction of caveolae to less than 3%.
Neg (failed) Localization (localize) of caveolin-1 in fibroblasts
1) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2837386 Disease Relevance 1.18 Pain Relevance 0.04
Absence of PTRF-CAVIN did not influence abundance of its binding partner caveolin-1 and caveolin-3.
Localization (abundance) of caveolin-1
2) Confidence 0.70 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2837386 Disease Relevance 1.17 Pain Relevance 0.04
1 mutations, especially because Cav1.1 ?
Localization (because) of Cav1
3) Confidence 0.59 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.20 Pain Relevance 0
Regions of overlap between the cav-1 and WT signals (Fig. 5A, yellow) were observed in these cells, consistent with co-localization at the plasma membrane.
Localization (localization) of cav-1 in plasma
4) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
As expected, WT maxi-K channels (Fig. 5A, red) were localized primarily on the plasma membrane, whereas cav-1 (Fig. 5A, green) was present both on the plasma membrane and intracellularly.
Localization (localized) of cav-1 in plasma
5) Confidence 0.54 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
mice demonstrating that ozone-induced alterations in Cav-1 are dependent on TNF-?
Localization (alterations) of Cav-1
6) Confidence 0.16 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.08 Pain Relevance 0
Lisanti and coworkers showed that caveolin-1 and caveolin-2 proteins, which are enriched in lipid rafts in a phosphorylated form, localized to FAC, whereas unphosphorylated caveolins localized to the ER[29].
Localization (localized) of caveolin-1
7) Confidence 0.05 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.08 Pain Relevance 0.05

General Comments

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