INT214981

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 2.71
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FANCC) nucleoplasm (FANCC) nucleus (FANCC)
protein complex assembly (FANCC) cytoplasm (FANCC)
Anatomy Link Frequency
myocardium 1
plasma 1
FANCC (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 12 94.64 High High
potassium channel 12 90.56 High High
cytokine 4 33.68 Quite Low
imagery 1 22.24 Low Low
Hsan 6 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 28 96.80 Very High Very High Very High
Breast Cancer 330 95.28 Very High Very High Very High
Stress 3 88.68 High High
Cancer 161 82.68 Quite High
Skin Cancer 96 73.52 Quite High
Metastasis 16 55.20 Quite High
Basal Cell Nevus Syndrome 30 43.44 Quite Low
Death 6 24.28 Low Low
Disease 18 5.00 Very Low Very Low Very Low
Fanconi Anemia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall alterations of FANCC showed significant association with deletion of BRCA2 in both group-A (P = 0.03) and group-B (P = 0.02).
FANCC Binding (alterations) of
1) Confidence 0.33 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0
Table 5 indicates significant association between alterations of FANCC (P = 0.004) and PTCH1 (P = 0.001) genes with their protein expression as seen by immunohistochemistry.
FANCC Binding (association) of
2) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.43 Pain Relevance 0
In FANCC, both deletion and methylation showed significant association in both groups (P = 0.004 and 0.002) while, in PTCH1 significant association was observed only in group-A (P = 0.002) [data no shown].


FANCC Binding (association) of
3) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.30 Pain Relevance 0
However, overall alterations of PHF2 showed significant association with either FANCC (P = 0.005) or XPA (P = 0.05) only in group-B [data not shown].


FANCC Binding (association) of
4) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.37 Pain Relevance 0
The association noted between FANCC alterations and adverse patient survival in either age group suggests it as a prognostic marker.
FANCC Binding (association) of
5) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.35 Pain Relevance 0
In FANCC, both deletion and methylation showed significant association in both groups (P = 0.004 and 0.002) while, in PTCH1 significant association was observed only in group-A (P = 0.002) [data no shown].


FANCC Binding (association) of
6) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.29 Pain Relevance 0
FAC have been shown to interact in signaling pathways with lipid raft proteins, although it's not clear how lipid rafts commute between ER bundles and plasma membrane rafts[29].
FAC Spec (clear) Binding (interact) of in plasma
7) Confidence 0.12 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.15 Pain Relevance 0.06
Our data further demonstrate that in CHO-K1 cells, the sigma-1 receptors target to the FAC via a specific drug response without a concomitant increase in the total focal adhesion contacts, as measured by the marker protein for FAC, talin (Fig. 3).
FAC Binding (target) of associated with adhesions
8) Confidence 0.08 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.34 Pain Relevance 0.31
These transient changes were observed in 48 h PO myocardium but were absent in both 4 h and 1 wk PO myocardium and correlate well with STAT3 activation and with our earlier observation in 48 h PO myocardium4, 5 that showed integrin activation and FAC formation, consisting of NTKs.
FAC Binding (formation) of in myocardium
9) Confidence 0.02 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.05 Pain Relevance 0

General Comments

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