INT214984

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 3.19
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FANCC) nucleoplasm (FANCC) nucleus (FANCC)
protein complex assembly (FANCC) cytoplasm (FANCC)
Anatomy Link Frequency
stem cell 1
FANCC (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 6 96.00 Very High Very High Very High
fortral 6 64.56 Quite High
Hsan 8 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
opioid receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 10 98.68 Very High Very High Very High
Breast Cancer 440 98.48 Very High Very High Very High
Cancer 210 94.56 High High
Metastasis 18 55.20 Quite High
Skin Cancer 128 46.16 Quite Low
Basal Cell Nevus Syndrome 40 16.08 Low Low
Disease 24 5.00 Very Low Very Low Very Low
Fanconi Anemia 16 5.00 Very Low Very Low Very Low
Pancreatic Cancer 16 5.00 Very Low Very Low Very Low
Freckles 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion, mutation and down-regulation of FANCC have also been reported in other malignancies [16-22].
Regulation (regulation) of FANCC
1) Confidence 0.40 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0
Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis and dysregulation of multiple DNA repair pathways as well as hedgehog dependent stem cell renewal pathway.



Regulation (alterations) of FANCC in stem cell associated with breast cancer
2) Confidence 0.24 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.15 Pain Relevance 0
Compared to XPA, overall frequencies of alterations in PHF2, FANCC and PTCH1 were higher (Figure 4).
Regulation (alterations) of FANCC
3) Confidence 0.24 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.48 Pain Relevance 0
Overall alterations of FANCC showed significant association with deletion of BRCA2 in both group-A (P = 0.03) and group-B (P = 0.02).
Regulation (alterations) of FANCC
4) Confidence 0.24 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0
Overall alterations of PHF2, FANCC and PTCH1 were comparatively higher than XPA.
Regulation (alterations) of FANCC
5) Confidence 0.24 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.14 Pain Relevance 0
Either age group exhibited high frequency of overall alterations in PHF2, FANCC and PTCH1 compared to XPA.
Regulation (alterations) of FANCC
6) Confidence 0.24 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.26 Pain Relevance 0
Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

Introduction

Regulation (Alterations) of FANCC associated with breast cancer
7) Confidence 0.24 Published 2008 Journal Mol Cancer Section Title Doc Link PMC2633285 Disease Relevance 0.58 Pain Relevance 0
Table 5 indicates significant association between alterations of FANCC (P = 0.004) and PTCH1 (P = 0.001) genes with their protein expression as seen by immunohistochemistry.
Regulation (alterations) of FANCC
8) Confidence 0.21 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.43 Pain Relevance 0
Although the state of localization of Kv1.4 potassium channels was not assessed with regard to the sigma-1 receptor ligands in this study, it is reasonable to propose that increased focal adhesion targeting of the sigma-1 receptors is a regulatory mechanism for modulation of Kv1.4 voltage-gated channels in FAC in CHO-K1 cells.
Regulation (modulation) of FAC associated with potassium channel and adhesions
9) Confidence 0.06 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.27 Pain Relevance 0.23

General Comments

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