INT214985

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.43
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FANCC) nucleoplasm (FANCC) nucleus (FANCC)
protein complex assembly (FANCC) cytoplasm (FANCC)
Anatomy Link Frequency
reticulum 1
FANCC (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 30 93.04 High High
fortral 30 86.64 High High
cocaine 10 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
opioid receptor 5 5.00 Very Low Very Low Very Low
Hsan 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 50 100.00 Very High Very High Very High
Cancer 36 94.48 High High
Stress 5 76.36 Quite High
Metastasis 12 64.20 Quite High
Breast Cancer 55 57.32 Quite High
Skin Cancer 16 5.00 Very Low Very Low Very Low
Basal Cell Nevus Syndrome 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 5 5.00 Very Low Very Low Very Low
Psychosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis showed both FANCC [Figure 6a–c] and PTCH1 proteins [Figure 6d–f] to be localized exclusively within the cytoplasm.
Localization (localized) of FANCC
1) Confidence 0.55 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.38 Pain Relevance 0
It is also possible that multiple intracellular or extracellular signal transduction pathways are triggered by sigma-1 receptor ligands that indirectly result in FAC translocation of the sigma-1 receptors.
Localization (translocation) of FAC
2) Confidence 0.20 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.28 Pain Relevance 0.19
Lisanti and coworkers showed that caveolin-1 and caveolin-2 proteins, which are enriched in lipid rafts in a phosphorylated form, localized to FAC, whereas unphosphorylated caveolins localized to the ER[29].
Localization (localized) of FAC
3) Confidence 0.19 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.08 Pain Relevance 0
Ligand activated sigma-1 receptors translocate into FAC from a pool of receptors stored in ER lipid rafts presumably for inhibition of Kv1.4 channels.
Localization (translocate) of FAC
4) Confidence 0.17 Published 2007 Journal J Mol Signal Section Abstract Doc Link PMC2045653 Disease Relevance 0.21 Pain Relevance 0.04
When the cells were rinsed with DMEM (without serum), instead of DPBS, the appearance of the sigma-1 receptors was also preserved in FAC, leading to the conclusion that the presence of divalent cations stabilized the sigma-1 receptors in the FAC, but did not appear to stimulate translocation of the sigma-1 receptors to the FAC.
Localization (translocation) of FAC
5) Confidence 0.15 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.13 Pain Relevance 0.12
The sigma-1 receptor immunocytochemical staining revealed that the receptors were localized to the nuclear envelope (NE), endoplasmic reticulum (ER) and the focal adhesion contacts (FAC).
Localization (localized) of FAC in reticulum associated with adhesions
6) Confidence 0.15 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.35 Pain Relevance 0.08

General Comments

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