INT215000

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.17
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
small intestine 1
T lymphocytes 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 12 100.00 Very High Very High Very High
Inflammation 22 98.84 Very High Very High Very High
cytokine 22 85.92 High High
imagery 13 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
TRP channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 98.84 Very High Very High Very High
Inflammatory Bowel Disease 4 87.04 High High
Cancer 50 85.48 High High
Pressure And Volume Under Development 5 75.88 Quite High
Metastasis 45 74.16 Quite High
Carcinoma 8 71.76 Quite High
Lung Cancer 30 67.40 Quite High
Charcot Marie Tooth Disease 3 59.96 Quite High
Ulcers 2 59.12 Quite High
Congenital Anomalies 16 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant treatment with indomethacin and gluten led to reduction of E-cadherin mRNA expression
Transcription (expression) of E-cadherin
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.19 Pain Relevance 0
Administration of indomethacin to gluten-sensitized mice led to more pronounced barrier dysfunction, which was accompanied by a mild pro-inflammatory shift with marked changes in EC ultra-structure, reduced E-cadherin mRNA levels in the proximal small intestine and generation of systemic antibody responses to intestinal microbiota.
Transcription (levels) of E-cadherin in small intestine associated with inflammation
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.38 Pain Relevance 0.09
Of note, there is no significant difference in the mRNA level of E-cadherin between SPC-A-1sci and SPC-A-1 cells.
Transcription (level) of E-cadherin
3) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.49 Pain Relevance 0
Immunofluorescence tests for the study of the expression of E-cadherin and TRPV6 calcium channel, IL-2+ and TNF+ cells, CD4+ and CD8+ T lymphocytes
Transcription (channel) of E-cadherin in T lymphocytes associated with calcium channel
4) Confidence 0.07 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.11 Pain Relevance 0.13

General Comments

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