INT215005

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfatc2) plasma membrane (Nfatc2) nucleus (Nfatc2)
DNA binding (Nfatc2) cytoplasm (Nfatc2)
Anatomy Link Frequency
nucleus 1
NFAT 1
Nfatc2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 105 67.84 Quite High
Calcium channel 12 54.44 Quite High
Inflammation 98 5.00 Very Low Very Low Very Low
antagonist 35 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 78.40 Quite High
Asthma 315 73.96 Quite High
Targeted Disruption 20 40.20 Quite Low
INFLAMMATION 107 5.00 Very Low Very Low Very Low
Eosinophilia 19 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 15 5.00 Very Low Very Low Very Low
Rhinitis 11 5.00 Very Low Very Low Very Low
Infection 11 5.00 Very Low Very Low Very Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dephosphorylation of the transcriptional factor NF-ATp (nuclear factor-activated T cells) by calcineurin is required for the translocation of NF-AT from the cytoplasm to the nucleus in response to an increased intracellular Ca2+ level [27].
Phosphorylation (Dephosphorylation) of NF-ATp in nucleus
1) Confidence 0.80 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.21 Pain Relevance 0.03
The NFAT family of transcription factors include the cytoplasmic NFAT transcription factors [NFATc1 (NFATc), NFATc2 (NFATp), NFATc3 (NFAT4, NFATx), NFATc4 (NFAT3), NFATc5] and nuclear NFAT (NFATn).
Phosphorylation (cytoplasmic) of NFATp in NFAT
2) Confidence 0.57 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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