INT21502

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 4.47
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn4a)
Anatomy Link Frequency
muscle 3
skeletal muscle 3
pore 1
brain 1
neurite 1
Scn4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 28 100.00 Very High Very High Very High
Nucleus accumbens 3 99.98 Very High Very High Very High
Delta opioid receptors 3 99.80 Very High Very High Very High
Endogenous opioid 3 99.10 Very High Very High Very High
depression 3 98.68 Very High Very High Very High
Opioid 10 98.60 Very High Very High Very High
Morphine 2 98.60 Very High Very High Very High
Dopamine 6 98.36 Very High Very High Very High
Analgesic 3 98.20 Very High Very High Very High
Enkephalin 9 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 240 99.46 Very High Very High Very High
Respiratory Failure 2 98.68 Very High Very High Very High
INFLAMMATION 44 97.20 Very High Very High Very High
Catalepsy 2 96.24 Very High Very High Very High
Cytomegalovirus Infection 3 95.80 Very High Very High Very High
Myotonia 7 95.76 Very High Very High Very High
Sarcoma 79 95.08 Very High Very High Very High
Infection 104 92.24 High High
Cold Sores 5 91.24 High High
Hypertrophy 1 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In studies described here, we have used RNase protection and Northern blot analyses to examine the expression of microI mRNA in different tissues and in neonatal, adult, and adult denervated muscle.
Spec (examine) Gene_expression (expression) of microI mRNA in muscle
1) Confidence 0.78 Published 1990 Journal Dev. Biol. Section Abstract Doc Link 2175278 Disease Relevance 0 Pain Relevance 0.28
Telomerase-immortalized human umbilical vein endothelial cells supporting KSHV stable latency (TIVE-LTC) expressed elevated levels of functional COX-2 and microsomal PGE2 synthase (m-PGES), and secreted the predominant eicosanoid inflammatory metabolite PGE2.
Gene_expression (expressed) of micro in endothelial cells associated with inflammation and herpes simplex virus
2) Confidence 0.75 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.67 Pain Relevance 0.36
We found that microI transcripts were not expressed in brain or heart, or in the myogenic cell line L6, even after differentiation to myotubes.
Neg (not) Gene_expression (expressed) of microI in brain
3) Confidence 0.67 Published 1990 Journal Dev. Biol. Section Abstract Doc Link 2175278 Disease Relevance 0 Pain Relevance 0.31
Ng may be linked to neurite formation by affecting expression of several microtubule related proteins.
Gene_expression (expression) of micro in neurite
4) Confidence 0.65 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1865092 Disease Relevance 0.14 Pain Relevance 0.11
We studied the properties of a sodium channel comprised only of S5-P-S6 region of the rat sodium channel alpha-subunit Nav1.4 (micro1pore).
Gene_expression (comprised) of Nav1.4 associated with sodium channel
5) Confidence 0.65 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15992775 Disease Relevance 0.15 Pain Relevance 0.41
As of September 2009, 10,883 miRNAs have been deposited in the microRNA database miRBase (Release 14: http://www.mirbase.org) [24], including 750 human, 604 Chimpanzee and 483 rhesus macaque miRNAs.
Gene_expression (database) of micro
6) Confidence 0.65 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2905361 Disease Relevance 0.61 Pain Relevance 0
Northern blot analysis indicates that the 8.5 kb microI transcript is preferentially expressed in skeletal muscle.
Gene_expression (expressed) of microI in skeletal muscle
7) Confidence 0.62 Published 1989 Journal Neuron Section Abstract Doc Link 2559760 Disease Relevance 0 Pain Relevance 0.31
Regulation of beta 1 mRNA expression closely parallels that of SkM1 alpha during development, after denervation in adult muscle, and in primary muscle culture, but does not follow SkM2 expression under any condition examined.
Gene_expression (expression) of SkM1 in muscle
8) Confidence 0.61 Published 1993 Journal Neuron Section Abstract Doc Link 8240813 Disease Relevance 0 Pain Relevance 0.19
State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides.
Gene_expression (expressed) of Nav1.4 in oocytes associated with sodium channel
9) Confidence 0.58 Published 2005 Journal Neurotoxicology Section Title Doc Link 15935211 Disease Relevance 0.08 Pain Relevance 0.53
We have recently described the cloning and functional expression of a new sodium channel subtype, microI, isolated from a denervated rat skeletal muscle cDNA library.
Gene_expression (expression) of microI in skeletal muscle associated with sodium channel
10) Confidence 0.53 Published 1990 Journal Dev. Biol. Section Abstract Doc Link 2175278 Disease Relevance 0 Pain Relevance 0.20
Dopamine depletion augments endogenous opioid-induced locomotion in the nucleus accumbens using both mu 1 and delta opioid receptors.
Gene_expression (using) of mu 1 in nucleus accumbens associated with nucleus accumbens, dopamine, endogenous opioid and delta opioid receptors
11) Confidence 0.52 Published 1995 Journal Psychopharmacology (Berl.) Section Title Doc Link 8524983 Disease Relevance 0 Pain Relevance 1.06
SCN4A exons with known SCM mutations were subsequently sequenced in families where no CLCN1 mutations were found.
Gene_expression (exons) of SCN4A
12) Confidence 0.48 Published 2007 Journal Neurology Section Body Doc Link 17998485 Disease Relevance 0.17 Pain Relevance 0
Thirteen mutations were identified in CLCN1 and five mutations were identified in SCN4A.
Gene_expression (identified) of SCN4A
13) Confidence 0.46 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 18337100 Disease Relevance 0.66 Pain Relevance 0.08
METHODS: The authors studied rat skeletal muscle mu1 (RSkM1) voltage-dependent Na+ channels or a mutant form heterologously coexpressed with rat brain Na+ channel accessory beta1, subunit in Xenopus oocytes.
Gene_expression (coexpressed) of mu1 in skeletal muscle
14) Confidence 0.45 Published 1999 Journal Anesthesiology Section Body Doc Link 10551601 Disease Relevance 0 Pain Relevance 0
This is consistent with the high and low affinity sites representing the mu 1 and mu 2 sites respectively.
Gene_expression (representing) of mu 1
15) Confidence 0.32 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.32
To test the hypothesis that the aortic wall is stretched without increasing aortic pressure (AP) during microgravity (microG), the AP, intrathoracic pressure (ITP), and aortic diameter (AD) were measured in anesthetized Sprague-Dawley rats during 4.5 s of microG produced by freefall.
Gene_expression (produced) of microG
16) Confidence 0.23 Published 2003 Journal Jpn. J. Physiol. Section Abstract Doc Link 12877771 Disease Relevance 0 Pain Relevance 0
With the goal of determining the minimum structure of the Na+ channel permeation pathway, we created two stable cell lines expressing the voltage-dependent rat skeletal muscle Na+ channel (micro1) with a polyhistidine tag on the C terminus (muHis) and pore-only micro1 (muPore) channels with S1-S4 in all domains removed.
Gene_expression (expressing) of micro1 in pore
17) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11973330 Disease Relevance 0.13 Pain Relevance 0.09
Expression of mu1 Na+ channels was found in cells maintained for more than 6 months after transfection; > 70% of cells expressed >/= 3 nA of Na+ current at +30 mV under whole-cell patch-clamp conditions.
Gene_expression (Expression) of mu1
18) Confidence 0.05 Published 1996 Journal Pflugers Arch. Section Abstract Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.12
The slow inactivation of cloned muscle alpha-subunit Na+ channels was investigated using a Chinese hamster ovary cell line permanently transfected with rat muscle mu1 cDNA.
Gene_expression (transfected) of mu1 in muscle
19) Confidence 0.04 Published 1996 Journal Pflugers Arch. Section Abstract Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.12
Evidence from a variety of experimental models has suggested the existence of mu 1, mu 2 and delta binding sites for morphine and the enkephalins in the central nervous system.
Gene_expression (existence) of mu 1 in central nervous system associated with central nervous system, enkephalin and morphine
20) Confidence 0.03 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319856 Disease Relevance 0.14 Pain Relevance 0.78

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