INT21503

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 45
Total Number 45
Disease Relevance 15.60
Pain Relevance 22.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
platelet 4
respiratory 2
knee joints 1
spinal cord 1
cleavage 1
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 92 100.00 Very High Very High Very High
cINOD 70 100.00 Very High Very High Very High
acular 36 100.00 Very High Very High Very High
COX2 13 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
tolerance 8 100.00 Very High Very High Very High
analgesia 7 100.00 Very High Very High Very High
cOX1 7 100.00 Very High Very High Very High
agonist 8 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 112 100.00 Very High Very High Very High
Toxicity 9 99.98 Very High Very High Very High
Colon Cancer 7 99.98 Very High Very High Very High
Nasal Polyps 2 99.88 Very High Very High Very High
Rhinitis 1 99.88 Very High Very High Very High
Diabetes Mellitus 9 99.82 Very High Very High Very High
Hyperalgesia 23 99.40 Very High Very High Very High
Asthma 3 99.30 Very High Very High Very High
Neuropathic Pain 9 99.16 Very High Very High Very High
Disease 17 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that ellagic acid may be effective against inflammation, may have a prolonged onset and duration of action, and may interact with known cyclooxygenase inhibitors.
cyclooxygenase Binding (interact) of associated with inflammation
1) Confidence 0.48 Published 2010 Journal J. Perianesth. Nurs. Section Abstract Doc Link 20656257 Disease Relevance 0.42 Pain Relevance 0.42
We conclude that protection by "mild irritants" against indomethacin-induced mucosal damage may involve increased cytoprotective PG generation, as shown for paracetamol and salicylic acid, or partial blocking of indomethacin binding at the cyclooxygenase receptor site, as shown for NaCl 5% and salicylic acid.
cyclooxygenase receptor site Binding (binding) of associated with paracetamol
2) Confidence 0.48 Published 1986 Journal Isr. J. Med. Sci. Section Abstract Doc Link 3098701 Disease Relevance 0 Pain Relevance 0.36
Nonsteroidal anti-inflammatory drugs produce their analgesic and adverse effects through interaction with cyclooxygenase in a variety of tissues.
cyclooxygenase Binding (interaction) of associated with inflammation, analgesic and cinod
3) Confidence 0.44 Published 2004 Journal J Clin Pharmacol Section Abstract Doc Link 15545314 Disease Relevance 0.42 Pain Relevance 0.36
This prompted us to study the interaction of salicylamide with aspirin and/or SA on rat platelet and cyclooxygenase.
cyclooxygenase Binding (interaction) of in platelet associated with aspirin
4) Confidence 0.42 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7846108 Disease Relevance 0 Pain Relevance 0.43
Although both alpha2-adrenergic agonists and cyclooxygenase inhibitors produce analgesia, their exact sites of action and interaction remain unclear.
cyclooxygenase Binding (interaction) of associated with agonist and analgesia
5) Confidence 0.37 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.37
The well-known mechanism underlying salicylate's action mainly involves the inhibition of cyclooxygenase and subsequent decrease in prostaglandin production.
cyclooxygenase Neg (inhibition) Binding (inhibition) of
6) Confidence 0.37 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18078964 Disease Relevance 0.29 Pain Relevance 0.31
Groups 5 and 6 investigated interactions between ellagic acid and cyclooxygenase inhibitors.
cyclooxygenase Binding (interactions) of
7) Confidence 0.36 Published 2010 Journal J. Perianesth. Nurs. Section Abstract Doc Link 20656257 Disease Relevance 0.38 Pain Relevance 0.45
IMPLICATIONS: Spinal injection of the alpha2-adrenergic agonist clonidine and the cyclooxygenase inhibitor ketorolac results in a synergistic interaction for antinociception in normal animals, suggesting that the combination of these drugs will enhance rather than detract from the analgesia of either alone.
cyclooxygenase Binding (interaction) of in Spinal associated with antinociception, acular, agonist, analgesia and clonidine
8) Confidence 0.36 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.85
Hyperalgesic behavior in diabetic rats is associated with both increased cyclooxygenase-2 protein and cyclooxygenase-mediated PGE(2) release.
cyclooxygenase Binding (associated) of associated with hyperalgesia and diabetes mellitus
9) Confidence 0.33 Published 2002 Journal Diabetes Section Abstract Doc Link 12086957 Disease Relevance 0.78 Pain Relevance 0.47
The structural interactions of melatonin with cyclooxygenase (COX), the pharmacological target of NSAIDs, were investigated using computer graphics applications.
cyclooxygenase Binding (interactions) of associated with cinod
10) Confidence 0.31 Published 2007 Journal Arzneimittelforschung Section Abstract Doc Link 18380411 Disease Relevance 0.52 Pain Relevance 0.40
When administered perorally, indomethacin inhibited cyclooxygenase product formation, phenidone inhibited 5-lipoxygenase product formation, and 3-amino-1-(m-[trifluoromethyl]-phenyl)-2-pyrazoline (BW 755C) inhibited formation of products of both pathways.
cyclooxygenase Binding (formation) of
11) Confidence 0.31 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3103625 Disease Relevance 0.59 Pain Relevance 0.53
Cyclooxygenase (COX) inhibitors may also play a role in morphine tolerance by interacting with both systems.
Cyclooxygenase Binding (interacting) of associated with tolerance and morphine
12) Confidence 0.30 Published 2000 Journal Br J Anaesth Section Abstract Doc Link 11094592 Disease Relevance 0 Pain Relevance 1.03
It is concluded that pravadoline and aminoalkylinodole analogs are inhibitory in several bioassay systems via a presynaptic mechanism which does not involve inhibition of cyclooxygenase, or the activation or inhibition of several known receptors.
cyclooxygenase Neg (inhibition) Binding (inhibition) of
13) Confidence 0.26 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175798 Disease Relevance 0 Pain Relevance 0.23
The pharmacodynamic studies show that these O-acyl derivatives of salicylic acid and diflunisal probably bind to, or combine with, the same site on the platelet cyclooxygenase as aspirin.
platelet cyclooxygenase Binding (bind) of in platelet associated with aspirin
14) Confidence 0.22 Published 1998 Journal J. Lab. Clin. Med. Section Abstract Doc Link 9851736 Disease Relevance 0.29 Pain Relevance 0.38
We have monitored levels of cyclooxygenase messenger RNA and prostaglandins in lumbar spinal cord in parallel with these behavioural responses (oedema, hyperalgesia and allodynia) and identified a marked increase in cyclooxygenase-2 messenger RNA (3-fold), maximal at 2-4 h after Freund's complete adjuvant, followed by a significant increase in 6-keto prostaglandin F1alpha and prostaglandin E2 which is maximal by 8 h.
cyclooxygenase Binding (levels) of in spinal cord associated with pressure and volume under development, hyperalgesia, allodynia and spinal cord
15) Confidence 0.21 Published 1997 Journal Neuroscience Section Abstract Doc Link 9153662 Disease Relevance 1.48 Pain Relevance 1.16
Because the prerequisite for accessing the cyclooxygenase by the drugs is interaction with the membrane, the focus of the current study was a comparison of how meloxicam, piroxicam, and tenoxicam interact with lipid monolayers used as models of biological membranes.
cyclooxygenase Binding (interaction) of
16) Confidence 0.19 Published 2010 Journal Langmuir Section Abstract Doc Link 20030324 Disease Relevance 0.16 Pain Relevance 0.16
Celecoxib, a cyclooxygenase (COX) 2 inhibitor, has not been reported to interact with methotrexate, but the mechanisms are unclear why the interaction did not occur.
cyclooxygenase Binding (interact) of associated with methotrexate
17) Confidence 0.10 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0.09 Pain Relevance 0.50
Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation.
cyclooxygenase Binding (injection) of in dorsal horn associated with nervous system injury, inflammation, dynorphin, dorsal horn, acular, calcitonin gene-related peptide and substance p
18) Confidence 0.09 Published 2003 Journal Neuroscience Section Title Doc Link 14568028 Disease Relevance 0.49 Pain Relevance 1.34
Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.
cyclooxygenase Binding (Interaction) of associated with inflammation and cox1
19) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17258197 Disease Relevance 0.32 Pain Relevance 0.27
It is hypothesized that meloxicam loosely binds to the cyclooxygenase-1 (COX-1) enzyme and salicylate can easily replace it.
cyclooxygenase-1 Binding (binds) of
20) Confidence 0.09 Published 2005 Journal Ideggyogy Sz Section Abstract Doc Link 16021964 Disease Relevance 0.26 Pain Relevance 0.14

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