INT215030

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghrhr) plasma membrane (Ghrhr) cytoplasm (Ghrhr)
signal transducer activity (Ghrhr)
Anatomy Link Frequency
nucleus 2
Ghrhr (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 17 41.04 Quite Low
Neurobehavioral 12 7.68 Low Low
Pain 12 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 100.00 Very High Very High Very High
Galactorrhea 4 99.66 Very High Very High Very High
Syndrome 185 99.38 Very High Very High Very High
Obesity 48 99.30 Very High Very High Very High
Cancer 47 79.44 Quite High
Acromegaly 18 78.08 Quite High
Metastasis 15 78.00 Quite High
Carcinoid 20 69.92 Quite High
Pancreatic Cancer 8 60.08 Quite High
Hyperphagia 48 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While early autopsies of PWS brains revealed a reduction in the size of the paraventricular nucleus containing fewer oxytocin-preducing neurons and a 30% reduction in GHRH-producing neurons in the nucleus arcuatus of the hypothalamus [36], more recent studies of hypothalami from six adult obese PWS individuals did not confirm a reduction of GHRH-neurons [37].
Negative_regulation (reduction) of GHRH in nucleus associated with syndrome and obesity
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.47 Pain Relevance 0
While early autopsies of PWS brains revealed a reduction in the size of the paraventricular nucleus containing fewer oxytocin-preducing neurons and a 30% reduction in GHRH-producing neurons in the nucleus arcuatus of the hypothalamus [36], more recent studies of hypothalami from six adult obese PWS individuals did not confirm a reduction of GHRH-neurons [37].
Negative_regulation (reduction) of GHRH in nucleus associated with syndrome and obesity
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.45 Pain Relevance 0
In addition, most patients also exhibit a moderate increase in serum prolactin concentration, which regresses after removal of the ectopic GHRH source, supporting the notion that GHRH is directly responsible for the hyperprolactinemia, a finding also present in hGHRH-transgenic mice [34].
Negative_regulation (present) of hGHRH-transgenic associated with targeted disruption and galactorrhea
3) Confidence 0.08 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.41 Pain Relevance 0

General Comments

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