INT215036

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.40
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gh, Trh) plasma membrane (Gh, Trh) nucleus (Gh, Trh)
cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
Gh (Mus musculus)
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 13 57.52 Quite High
antagonist 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Thoracotomy 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Galactorrhea 4 99.66 Very High Very High Very High
Cancer 47 97.96 Very High Very High Very High
Metastasis 15 97.24 Very High Very High Very High
Targeted Disruption 2 93.48 High High
Carcinoid 20 86.40 High High
Syndrome 9 76.80 Quite High
Pancreatic Cancer 8 76.56 Quite High
Acromegaly 18 70.48 Quite High
Pituitary Cancer 6 25.20 Quite Low
Adenoma 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After surgery, hyperprolactinemia normalized, but GH still increased after TRH administration, suggesting that GHRH was still being produced by tumor remnants or metastases in two patients (nos. 2 and 3).
GH Positive_regulation (increased) of Gene_expression (administration) of TRH associated with galactorrhea, cancer and metastasis
1) Confidence 0.08 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.40 Pain Relevance 0.06

General Comments

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