INT215070

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.23
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
peritoneal macrophages 2
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 100.00 Very High Very High Very High
cytokine 60 98.08 Very High Very High Very High
Inflammatory mediators 15 77.84 Quite High
Inflammation 54 68.76 Quite High
antagonist 16 50.00 Quite Low
Inflammatory response 33 7.28 Low Low
chemokine 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 212 99.76 Very High Very High Very High
Post-traumatic Stress Disorder 7 99.24 Very High Very High Very High
Sepsis 152 97.40 Very High Very High Very High
Anxiety Disorder 13 91.84 High High
Shock 10 89.68 High High
Endotoxemia 14 80.72 Quite High
INFLAMMATION 105 77.84 Quite High
Disease 18 50.56 Quite High
Brain Tumor 47 50.00 Quite Low
Hemorrhagic Shock 2 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although EGCG-mediated suppression of HMGB1 cell surface clustering may not account for its inhibitory effects on LPS-induced HMGB1 release, it likely underlies its inhibitory effects on cytokine activities of the secreted HMGB1.
Regulation (effects) of Localization (release) of HMGB1 associated with cytokine
1) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.34 Pain Relevance 0.20
To assess the effects of radiation on HMGB1 release from tumor cell lines, cells were irradiated with 20 Gy of gamma radiation for 30 min at room temperature.
Regulation (effects) of Localization (release) of HMGB1 associated with cancer
2) Confidence 0.25 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.38 Pain Relevance 0
Intriguingly, C5L2 may play an important role in the regulation of HMGB1 release, because
         HMGB1 release was somewhat impaired in C5L2-deficient mice following septic insult, and
         C5L2-deficient peritoneal macrophages following LPS stimulation (Ref. 110). 
Regulation (regulation) of Localization (release) of HMGB1 in peritoneal macrophages
3) Confidence 0.24 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.02 Pain Relevance 0.20
Animals exposed to PCP on P7 did not differ from controls on measures of locomotor activity, sensorimotor function, water maze acquisition or retention at P30 or P75, or of the ASR/PPI.
Neg (not) Regulation (differ) of Localization (retention) of P30 associated with post-traumatic stress disorder and eae
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.50 Pain Relevance 0.09

General Comments

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