INT215071

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 22.03
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
monocyte 9
immune cells 6
macrophage 3
hepatocytes 2
puncture 2
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 829 100.00 Very High Very High Very High
agonist 77 100.00 Very High Very High Very High
chemokine 89 99.04 Very High Very High Very High
ischemia 83 98.32 Very High Very High Very High
Inflammation 609 95.04 Very High Very High Very High
Inflammatory stimuli 18 92.72 High High
Inflammatory response 375 90.08 High High
Arthritis 6 72.48 Quite High
cINOD 45 68.32 Quite High
dexamethasone 27 65.68 Quite High
Disease Link Frequency Relevance Heat
Glioblastoma 150 100.00 Very High Very High Very High
Sepsis 1788 99.98 Very High Very High Very High
Hemorrhagic Shock 79 99.98 Very High Very High Very High
Glioma 115 99.86 Very High Very High Very High
Infection 200 99.84 Very High Very High Very High
Cancer 1108 99.80 Very High Very High Very High
Cv Unclassified Under Development 86 98.32 Very High Very High Very High
Brain Tumor 235 98.20 Very High Very High Very High
Endotoxemia 232 97.88 Very High Very High Very High
Melanoma 40 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that dying glioma cells released HMGB1, as a result of infection and killing with Ad-TK (+GCV); HMGB1 in turn stimulated TLR2-dependent NF?
Positive_regulation (result) of Localization (released) of HMGB1 associated with infection and glioma
1) Confidence 0.63 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.06 Pain Relevance 0.04
The pathogenesis of lethal sepsis remains obscure, but is mediated in part by excessive release of early (e.g., TNF and IL-1) and late (e.g., HMGB1) proinflammatory cytokines.
Positive_regulation (mediated) of Localization (release) of HMGB1 associated with sepsis and cytokine
2) Confidence 0.59 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.04 Pain Relevance 0.19
Even at concentrations up to 10 µM, catechin or ethyl gallate did not affect LPS-induced HMGB1 release (Fig. 4B), indicating that functional groups of both catechin and gallate are needed for EGCG's HMGB1-inhibiting properties.


Positive_regulation (induced) of Localization (release) of HMGB1
3) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.16 Pain Relevance 0.03
EGCG inhibits HMGB1-induced cytokine release
Positive_regulation (induced) of Localization (release) of HMGB1 associated with cytokine
4) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.42 Pain Relevance 0.10
Whereas concurrent administration of EGCG was most effective in inhibiting LPS-induced HMGB1 release, significant inhibition was still achieved when it was added 2 to 6 h after LPS (Fig. 3).
Positive_regulation (induced) of Localization (release) of HMGB1
5) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.21
Taken together, these experimental data suggest that EGCG selectively inhibits LPS-induced release of HMGB1, TNF, IL-6, IL-12, and chemokines, without affecting LPS-induced release of G-CSF, P-selection, LIX, IL-1?
Positive_regulation (induced) of Localization (release) of HMGB1 associated with chemokine
6) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.29
Similarly, it is not yet known whether EGCG inhibits LPS-induced HMGB1 release through inhibiting LPS-induced cytoplasmic translocation, or post-translational modification (such as acetylation or phosphorylation).
Positive_regulation (induced) of Localization (release) of HMGB1
7) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.22 Pain Relevance 0.04
EGCG attenuates sepsis-induced systemic HMGB1 accumulation
Positive_regulation (induced) of Localization (accumulation) of HMGB1 associated with sepsis
8) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.23 Pain Relevance 0.16
In conclusion, we demonstrated a major tea component, EGCG, recapitulated green tea's HMGB1-inhibiting activities, and dose-dependently abrogated LPS-induced HMGB1 release in macrophage/monocyte cultures.
Positive_regulation (induced) of Localization (release) of HMGB1 in monocyte
9) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.89 Pain Relevance 0.07
Although EGCG-mediated suppression of HMGB1 cell surface clustering may not account for its inhibitory effects on LPS-induced HMGB1 release, it likely underlies its inhibitory effects on cytokine activities of the secreted HMGB1.
Positive_regulation (induced) of Localization (release) of HMGB1 associated with cytokine
10) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.34 Pain Relevance 0.20
In light of the capacity of EGCG in inhibiting LPS-induced HMGB1 release and cytokine activities, we explored its efficacy in animal models of lethal endotoxemia and sepsis (induced by cecal ligation and puncture).
Positive_regulation (induced) of Localization (release) of HMGB1 in puncture associated with endotoxemia, sepsis and cytokine
11) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.52 Pain Relevance 0.17
Delayed administration of EGCG still attenuated endotoxin-induced HMGB1 release
Positive_regulation (induced) of Localization (release) of HMGB1
12) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.06 Pain Relevance 0.27
In light of the capacity of EGCG in attenuating LPS-induced HMGB1 release, we explored its efficacy in animal model of lethal endotoxemia.
Positive_regulation (induced) of Localization (release) of HMGB1 associated with endotoxemia
13) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.39 Pain Relevance 0.03
Our results show an increase in extracellular HMGB1 (approximately 30 kDa MW detected by western blot) released from Ad-TK + GCV treated GL26 tumor cells in vitro 48 h and 72 h after treatment (Figure 7A).
Positive_regulation (increase) of Localization (released) of HMGB1 associated with cancer
14) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.03 Pain Relevance 0.03
Irradiation (Figure 9E–9H) and temozolomide (Figure 9I–9L) treatments also caused a significant increase (*, p < 0.05) in the levels of HMGB1 released from GL26 (?
Positive_regulation (caused) of Localization (released) of HMGB1
15) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.87 Pain Relevance 0
In this study, we evaluated the capacity of tea catechins in inhibiting endotoxin-induced HMGB1 release and/or cytokine activities, and explored their therapeutic potential in animal model of sepsis.


Positive_regulation (induced) of Localization (release) of HMGB1 associated with sepsis and cytokine
16) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.56 Pain Relevance 0.21
A major tea catechin, EGCG, dose-dependently abrogated endotoxin-induced HMGB1 release, with an estimated IC50<1.0 µM (Fig. 1A).
Positive_regulation (induced) of Localization (release) of HMGB1
17) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0
However, it was previously unknown if green tea catechins can attenuate endotoxin-induced HMGB1 release or cytokine activities.
Positive_regulation (induced) of Localization (release) of HMGB1 associated with cytokine
18) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.74 Pain Relevance 0.30
For instance, it is not known whether EGCG-mediated suppression of HMGB1 release is dependent on its antioxidant activities, because some antioxidants (e.g., catechin, ethyl gallate) failed to inhibit LPS-induced HMGB1 release.
Spec (whether) Positive_regulation (dependent) of Localization (release) of HMGB1
19) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.17 Pain Relevance 0.03
HMGB1 is actively
               secreted by innate immune cells in response to exogenous bacterial products (e.g.
               
Positive_regulation (actively) of Localization (secreted) of HMGB1 in immune cells
20) Confidence 0.45 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.31 Pain Relevance 0.08

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