INT215074

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 28
Total Number 31
Disease Relevance 15.09
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
monocyte 9
macrophage 5
liver 4
RAW 264 2
puncture 2
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 903 100.00 Very High Very High Very High
chemokine 76 99.04 Very High Very High Very High
ischemia 76 98.88 Very High Very High Very High
Nicotine 30 98.52 Very High Very High Very High
Inflammation 552 97.80 Very High Very High Very High
Inflammatory response 359 90.68 High High
Inflammatory mediators 110 82.24 Quite High
Pain 41 81.28 Quite High
cINOD 35 68.32 Quite High
dexamethasone 21 65.68 Quite High
Disease Link Frequency Relevance Heat
Sepsis 1874 99.92 Very High Very High Very High
Multiple Organ Failure 16 99.44 Very High Very High Very High
Cv Unclassified Under Development 90 98.88 Very High Very High Very High
Bacteremia 4 98.56 Very High Very High Very High
Adult Respiratory Distress Syndrome 46 98.04 Very High Very High Very High
INFLAMMATION 1028 97.80 Very High Very High Very High
Disease 197 97.28 Very High Very High Very High
Endotoxemia 280 96.88 Very High Very High Very High
Gynecological Disease 7 95.76 Very High Very High Very High
Stress 51 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since receptor clustering-disrupting agents (such as nystatin or MCD) can prevent LPS-induced cytokine production [38], it will thus be interesting to determine whether EGCG inhibits HMGB1 release via similar mechanisms.
Spec (whether) Negative_regulation (inhibits) of Localization (release) of HMGB1 associated with cytokine
1) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.33 Pain Relevance 0.21
The mechanism underlying EGCG-mediated suppression of HMGB1 release remains elusive.
Negative_regulation (suppression) of Localization (release) of HMGB1
2) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.05 Pain Relevance 0
For instance, it is not known whether EGCG-mediated suppression of HMGB1 release is dependent on its antioxidant activities, because some antioxidants (e.g., catechin, ethyl gallate) failed to inhibit LPS-induced HMGB1 release.
Spec (whether) Negative_regulation (suppression) of Localization (release) of HMGB1
3) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.17 Pain Relevance 0.03
In contrast, at concentrations that abrogated endotoxin-induced HMGB1 release, EGCG only partially attenuated endotoxin-induced TNF secretion (Fig. 1B), but did not inhibit endotoxin-induced nitric oxide release (Fig. 1C).
Negative_regulation (abrogated) of Localization (release) of HMGB1
4) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0
Despite the fact that EGCG failed to inhibit LPS-induced nitric oxide (Fig. 1C), it dose-dependently suppressed HMGB1-induced release of nitric oxide in RAW 264.7 cells (Fig. 7A, bottom panel), or primary MuMACs (Fig. 7B), supporting the notion that LPS and HMGB1 use distinct mechanisms to activate innate immune cells [29], [37].
Negative_regulation (suppressed) of Localization (release) of HMGB1 in RAW 264
5) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.38 Pain Relevance 0.12
In this study, we evaluated the capacity of tea catechins in inhibiting endotoxin-induced HMGB1 release and/or cytokine activities, and explored their therapeutic potential in animal model of sepsis.


Negative_regulation (inhibiting) of Localization (release) of HMGB1 associated with sepsis and cytokine
6) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.62 Pain Relevance 0.21
For instance, it is not known whether EGCG-mediated suppression of HMGB1 release is dependent on its antioxidant activities, because some antioxidants (e.g., catechin, ethyl gallate) failed to inhibit LPS-induced HMGB1 release.
Negative_regulation (inhibit) of Localization (release) of HMGB1
7) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.20 Pain Relevance 0.03
A major tea catechin, EGCG, dose-dependently abrogated endotoxin-induced HMGB1 release, with an estimated IC50<1.0 µM (Fig. 1A).
Negative_regulation (abrogated) of Localization (release) of HMGB1
8) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0
Here we report that a major component, EGCG, recapitulated HMGB1-inhibiting activities of green tea, and dose-dependently inhibited LPS-induced HMGB1 release in macrophage/monocyte cultures.
Negative_regulation (inhibited) of Localization (release) of HMGB1 in monocyte
9) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.03
In conclusion, we demonstrated a major tea component, EGCG, recapitulated green tea's HMGB1-inhibiting activities, and dose-dependently abrogated LPS-induced HMGB1 release in macrophage/monocyte cultures.
Negative_regulation (abrogated) of Localization (release) of HMGB1 in monocyte
10) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.89 Pain Relevance 0.07
In light of the capacity of EGCG in inhibiting LPS-induced HMGB1 release and cytokine activities, we explored its efficacy in animal models of lethal endotoxemia and sepsis (induced by cecal ligation and puncture).
Negative_regulation (inhibiting) of Localization (release) of HMGB1 in puncture associated with endotoxemia, sepsis and cytokine
11) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.52 Pain Relevance 0.17
Similarly, it is not yet known whether EGCG inhibits LPS-induced HMGB1 release through inhibiting LPS-induced cytoplasmic translocation, or post-translational modification (such as acetylation or phosphorylation).
Spec (whether) Negative_regulation (inhibits) of Localization (release) of HMGB1
12) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.22 Pain Relevance 0.04
We recently discovered that green tea, brewed from the leaves of the plant, Camellia sinensis, is effective in inhibiting bacterial endotoxin-induced HMGB1 release [31], but the active components responsible for its activities were previously unknown.
Negative_regulation (inhibiting) of Localization (release) of HMGB1
13) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.06
In primary MuMACs, EGCG also abrogated LPS-induced HMGB1 release, but similarly failed to inhibit LPS-induced nitric oxide release (Fig. 2A).
Negative_regulation (abrogated) of Localization (release) of HMGB1
14) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.10
It is intriguing to consider whether EGCG could inhibit HMGB1 release if added after LPS stimulation.
Negative_regulation (inhibit) of Localization (release) of HMGB1
15) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.05 Pain Relevance 0.25
Taken together, these experimental data suggest that EGCG selectively inhibits LPS-induced release of HMGB1, TNF, IL-6, IL-12, and chemokines, without affecting LPS-induced release of G-CSF, P-selection, LIX, IL-1?
Negative_regulation (inhibits) of Localization (release) of HMGB1 associated with chemokine
16) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.29
EGCG inhibits HMGB1-induced cytokine release
Negative_regulation (inhibits) of Localization (release) of HMGB1 associated with cytokine
17) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.42 Pain Relevance 0.10
Therefore, agents proven clinically safe, and yet still capable of attenuating HMGB1 release may hold potential in the prevention and treatment of inflammatory diseases.
Negative_regulation (attenuating) of Localization (release) of HMGB1 associated with inflammation and disease
18) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.41 Pain Relevance 0.35
Indeed, ethyl pyruvate, stearoyl lysophosphatidylcholine, and nicotine have been shown to be efficacious in ameliorating experimental sepsis by preventing HMGB1 release during experimental sepsis [156–158].
Negative_regulation (preventing) of Localization (release) of HMGB1 associated with nicotine and sepsis
19) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.63 Pain Relevance 0.09
The inhibition of HMGB1 secretion or activity prevents endotoxin- or bacteremia-induced multiple organ failure [11].
Negative_regulation (inhibition) of Localization (secretion) of HMGB1 associated with multiple organ failure and bacteremia
20) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 1.52 Pain Relevance 0.22

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