INT215078

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.30
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
lung 2
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 110 98.36 Very High Very High Very High
ischemia 70 95.28 Very High Very High Very High
Inflammation 55 91.84 High High
cva 35 84.56 Quite High
agonist 5 74.48 Quite High
vagus nerve 9 72.32 Quite High
Inflammatory response 35 66.72 Quite High
Nicotine 3 59.84 Quite High
Central nervous system 2 30.40 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 99.98 Very High Very High Very High
Sepsis 171 99.68 Very High Very High Very High
Pressure And Volume Under Development 4 98.76 Very High Very High Very High
Cv Unclassified Under Development 74 95.28 Very High Very High Very High
INFLAMMATION 88 91.84 High High
Lung Injury 2 88.28 High High
Injury 61 87.84 High High
Hemorrhage 36 84.56 Quite High
Adult Respiratory Distress Syndrome 10 83.28 Quite High
Infection 15 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we propose that EGCG rescues mice from lethal sepsis partly through inhibiting systemic HMGB1 accumulation, as well as HMGB1-induced release IL-6 and KC.
Negative_regulation (inhibiting) of Gene_expression (accumulation) of HMGB1 associated with sepsis
1) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.02 Pain Relevance 0.09
In mechanical stress groups, HMGB1 was already detected after 0.96?
Negative_regulation (groups) of Gene_expression (detected) of HMGB1 associated with stress
2) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.11 Pain Relevance 0.35
Therefore, we propose that EGCG rescues mice from lethal sepsis partly through inhibiting systemic HMGB1 accumulation, as well as HMGB1-induced release IL-6 and KC.
Negative_regulation (inhibiting) of Gene_expression (accumulation) of HMGB1 associated with sepsis
3) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.02 Pain Relevance 0.09
Accordingly, HMGB1 antibodies reduced this neutrophil accumulation, edema, and lung permeability.
Negative_regulation (reduced) of Gene_expression (antibodies) of HMGB1 in lung associated with pressure and volume under development
4) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 1.14 Pain Relevance 0.43

General Comments

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