INT215085

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 16.81
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
liver 9
cortex 2
lungs 1
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 261 99.52 Very High Very High Very High
cytokine 280 99.44 Very High Very High Very High
Inflammation 499 96.40 Very High Very High Very High
Inflammatory response 172 95.48 Very High Very High Very High
monoamine 3 93.44 High High
Hippocampus 14 90.60 High High
Inflammatory marker 2 83.76 Quite High
Inflammatory mediators 75 79.20 Quite High
Glutamate 11 73.04 Quite High
Nicotine 8 69.36 Quite High
Disease Link Frequency Relevance Heat
Sepsis 499 100.00 Very High Very High Very High
Cv Unclassified Under Development 244 99.52 Very High Very High Very High
Injury 306 99.28 Very High Very High Very High
Hepatitis 8 99.24 Very High Very High Very High
Death 49 98.36 Very High Very High Very High
Hemorrhagic Shock 73 98.08 Very High Very High Very High
Disease 180 96.64 Very High Very High Very High
Cognitive Disorder 38 96.48 Very High Very High Very High
INFLAMMATION 741 96.40 Very High Very High Very High
Brain Tumor 141 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of cell culture supernatants revealed increased levels of HMGB1 following treatment with either Ad-TK (+GCV), radiation, or temozolomide (Figure 8).
Positive_regulation (increased) of Gene_expression (levels) of HMGB1
1) Confidence 0.63 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.73 Pain Relevance 0
In murine models of endotoxaemia and sepsis (induced by CLP), HMGB1 is first detectable
           in the circulation 8 h after the onset of lethal endotoxaemia and sepsis,
           subsequently increasing to plateau levels from 16 to 32 h (Refs 51, 80).
           
Positive_regulation (increasing) of Gene_expression (detectable) of HMGB1 associated with sepsis
2) Confidence 0.62 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.54 Pain Relevance 0.25
Although delayed administration of EGCG did not attenuate circulating TNF levels at 52 h after the onset of sepsis (Fig. 6C, left panel), it did significantly attenuate circulating levels of HMGB1 (Fig. 6C, right panel, P<0.05), suggesting that EGCG confers protection against lethal sepsis partly by attenuating systemic HMGB1 accumulation.


Positive_regulation (circulating) of Gene_expression (levels) of HMGB1 associated with sepsis
3) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.43 Pain Relevance 0.11
Figure 9A–9D reveals statistically significant increases (*p < 0.05 versus mock and Ad0) in HMGB1 levels in the supernatants of GL26 (?
Positive_regulation (increases) of Gene_expression (levels) of HMGB1
4) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.73 Pain Relevance 0
Levels of HMGB1 were increased in the serum of mice bearing either GL261 (*, p < 0.05; ?
Positive_regulation (increased) of Gene_expression (Levels) of HMGB1
5) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.00 Pain Relevance 0
Furthermore, HMGB1 levels in the low (<100 kDa) serum fraction were
       significantly higher in septic patients who died of sepsis than those who survived (Ref.
         51). 
Positive_regulation (higher) of Gene_expression (levels) of HMGB1 associated with sepsis
6) Confidence 0.45 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.83 Pain Relevance 0.21
This late appearance of circulating HMGB1 precedes and parallels the onset of animal
           lethality from endotoxaemia or sepsis, and distinguishes HMGB1 from TNF and other early
           proinflammatory cytokines (Ref. 96) (Fig. 3). 
Positive_regulation (circulating) of Gene_expression (precedes) of HMGB1 associated with sepsis and cytokine
7) Confidence 0.45 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.32 Pain Relevance 0.23
Indeed, administration of
         stearoyl LPC significantly attenuated circulating HMGB1 levels (Ref. 47), indicating that stearoyl LPC protects against experimental
         sepsis partly by facilitating elimination of invading pathogens and partly by attenuating
         systemic HMGB1 accumulation (Ref. 130).


Positive_regulation (circulating) of Gene_expression (levels) of HMGB1 associated with sepsis
8) Confidence 0.45 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.36 Pain Relevance 0.16
In their study, HMGB1 was undetectable in the systemic circulation before human liver transplantation, and the peak value appeared 10?
Positive_regulation (circulation) of Gene_expression (undetectable) of HMGB1 in liver
9) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.04 Pain Relevance 0.34
min of warm ischemia of the liver [18], suggesting an active production of HMGB1 in addition to a cell damage-associated release.
Positive_regulation (active) of Gene_expression (production) of HMGB1 in liver associated with ischemia
10) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 0.95 Pain Relevance 0.32
Tsung observed in a mouse ischemia/reperfusion model that HMGB1 protein expression in the liver increased with time up to 24?
Positive_regulation (increased) of Gene_expression (expression) of HMGB1 in liver associated with ischemia
11) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.00 Pain Relevance 0.33
At these time points, levels of HMGB-1 were also elevated and prompted us to further investigate the role of these factors in the development of cognitive dysfunction.
Positive_regulation (elevated) of Gene_expression (levels) of HMGB-1 associated with cognitive disorder
12) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.12 Pain Relevance 0.43
Furthermore, whilst the cytokine expression profile induced by HMGB1 versus LPS was similar, a slower induction of TNF?
Positive_regulation (by) of Gene_expression (versus) of HMGB1 associated with cytokine
13) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.51 Pain Relevance 0.37
Furthermore, whilst the cytokine expression profile induced by HMGB1 versus LPS was similar, a slower induction of TNF?
Positive_regulation (induction) of Gene_expression (versus) of HMGB1 associated with cytokine
14) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.51 Pain Relevance 0.37
Furthermore, whilst the cytokine expression profile induced by HMGB1 versus LPS was similar, a slower induction of TNF?
Positive_regulation (versus) of Gene_expression (versus) of HMGB1 associated with cytokine
15) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.51 Pain Relevance 0.37
Marked increase in HMGB1 levels in serum, lungs, and liver was detected within 2?
Positive_regulation (increase) of Gene_expression (levels) of HMGB1 in liver
16) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 1.19 Pain Relevance 0.10
Microinjection of HMGB1 into the cortex of mice results in increased expression of iNOS and IL-1?
Positive_regulation (results) of Gene_expression (Microinjection) of HMGB1 in cortex
17) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.81 Pain Relevance 0.17
, HMGB1 exposure resulted in activation of both IKK-?
Positive_regulation (resulted) of Gene_expression (exposure) of HMGB1
18) Confidence 0.20 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.04 Pain Relevance 0.30
Marked increase in HMGB1 levels in serum, lungs, and liver was detected within 2?
Positive_regulation (increase) of in lungs Gene_expression (levels) of HMGB1 in liver
19) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 1.19 Pain Relevance 0.10

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