INT215091

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.18
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
glial cells 2
cardiomyocytes 2
colon 2
nociceptors 2
body 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 60 98.98 Very High Very High Very High
antagonist 27 98.00 Very High Very High Very High
antiepileptic Drug 47 95.04 Very High Very High Very High
Calcitonin gene-related peptide 21 74.56 Quite High
Nerve growth factor 20 73.04 Quite High
Bioavailability 1 58.24 Quite High
cytokine 32 58.12 Quite High
anticonvulsant 4 56.48 Quite High
bradykinin 5 50.40 Quite High
Mechanotransduction 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 82 96.52 Very High Very High Very High
Rheumatoid Arthritis 34 94.00 High High
Endotoxemia 13 87.44 High High
Nociception 27 63.56 Quite High
Epilepsy 24 56.88 Quite High
Status Epilepticus 2 53.88 Quite High
Sepsis 52 50.00 Quite Low
Arrhythmia Under Development 19 48.92 Quite Low
Embryonic Lethality 2 39.28 Quite Low
Hypertrophy 1 25.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SA currents, which are present in around 30% of all nociceptors (Hu & Lewin, 2006; Lechner et al. 2009), were not affected by application of UTP (Fig. 2A and B).


Neg (not) Regulation (affected) of Localization (application) of Fig in nociceptors associated with nociceptor
1) Confidence 0.27 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.46 Pain Relevance 0.51
Basic pharmacokinetic parameters are the factors in the body that affects the drug from the time it is taken, including absorption, distribution, metabolism and excretion (Fig. 2).
Regulation (affects) of Localization (excretion) of Fig in body
2) Confidence 0.18 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746576 Disease Relevance 0.11 Pain Relevance 0.25
The competitive Y1 antagonist, BIBO3304, caused sustained elevations in Isc that were maximal at 15 min in WT mouse and human colon mucosa and neither of these effects was sensitive to TTX pretreatment (Fig. 1A,C).
Regulation (sensitive) of Localization (pretreatment) of Fig in colon associated with antagonist
3) Confidence 0.15 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0 Pain Relevance 0.14
The calcium response to thrombin and PAR1-AP in glial cells was ablated by genetic deletion of PAR1 but was unaffected by deletion of PAR2 (Fig. 2E).
Neg (unaffected) Regulation (unaffected) of Localization (deletion) of Fig in glial cells
4) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.27
Although the expression and localization of the adherens junction protein N-cadherin was unaffected (Fig. 7 B), the localization of the gap junction protein Connexin 43 (Cx43) was altered in KO cardiomyocytes 8 wk after induction (Fig. 7 C).
Neg (unaffected) Regulation (unaffected) of Localization (localization) of Fig in cardiomyocytes associated with targeted disruption
5) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.39 Pain Relevance 0
Even at concentrations up to 10 ┬ÁM, catechin or ethyl gallate did not affect LPS-induced HMGB1 release (Fig. 4B), indicating that functional groups of both catechin and gallate are needed for EGCG's HMGB1-inhibiting properties.


Regulation (affect) of Localization (release) of Fig
6) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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