INT215093

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.90
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Hmgb1) cell morphogenesis (Hmgb1) intracellular (Tlr4)
DNA binding (Hmgb1) signal transduction (Tlr4) extracellular space (Hmgb1)
Anatomy Link Frequency
monocyte 6
macrophage 2
puncture 2
Tlr4 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 256 99.80 Very High Very High Very High
Inflammatory response 48 76.96 Quite High
Inflammation 64 67.60 Quite High
chemokine 16 20.96 Low Low
Pain 16 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Nicotine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endotoxemia 104 96.88 Very High Very High Very High
Sepsis 416 96.24 Very High Very High Very High
INFLAMMATION 104 76.96 Quite High
Cancer 16 69.60 Quite High
Hypersensitivity 8 65.52 Quite High
Disease 24 24.08 Low Low
Fever 24 5.00 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of the capacity of EGCG in inhibiting LPS-induced HMGB1 release and cytokine activities, we explored its efficacy in animal models of lethal endotoxemia and sepsis (induced by cecal ligation and puncture).
LPS Positive_regulation (induced) of Localization (release) of HMGB1 in puncture associated with endotoxemia, sepsis and cytokine
1) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.52 Pain Relevance 0.17
In primary MuMACs, EGCG also abrogated LPS-induced HMGB1 release, but similarly failed to inhibit LPS-induced nitric oxide release (Fig. 2A).
LPS Neg (failed) Positive_regulation (induced) of Localization (release) of HMGB1
2) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.10
For instance, it is not known whether EGCG-mediated suppression of HMGB1 release is dependent on its antioxidant activities, because some antioxidants (e.g., catechin, ethyl gallate) failed to inhibit LPS-induced HMGB1 release.
LPS Neg (not) Spec (whether) Positive_regulation (induced) of Localization (release) of HMGB1
3) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.20 Pain Relevance 0.03
Although EGCG-mediated suppression of HMGB1 cell surface clustering may not account for its inhibitory effects on LPS-induced HMGB1 release, it likely underlies its inhibitory effects on cytokine activities of the secreted HMGB1.
LPS Positive_regulation (induced) of Localization (release) of HMGB1 associated with cytokine
4) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.34 Pain Relevance 0.20
Here we report that a major component, EGCG, recapitulated HMGB1-inhibiting activities of green tea, and dose-dependently inhibited LPS-induced HMGB1 release in macrophage/monocyte cultures.
LPS Positive_regulation (induced) of Localization (release) of HMGB1 in monocyte
5) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.03
In conclusion, we demonstrated a major tea component, EGCG, recapitulated green tea's HMGB1-inhibiting activities, and dose-dependently abrogated LPS-induced HMGB1 release in macrophage/monocyte cultures.
LPS Positive_regulation (induced) of Localization (release) of HMGB1 in monocyte
6) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.89 Pain Relevance 0.07
In conclusion, we demonstrated a major tea component, EGCG, recapitulated green tea's HMGB1-inhibiting activities, and dose-dependently abrogated LPS-induced HMGB1 release in macrophage/monocyte cultures.
LPS Positive_regulation (induced) of in macrophage Localization (release) of HMGB1 in monocyte
7) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.89 Pain Relevance 0.07
Here we report that a major component, EGCG, recapitulated HMGB1-inhibiting activities of green tea, and dose-dependently inhibited LPS-induced HMGB1 release in macrophage/monocyte cultures.
LPS Positive_regulation (induced) of in macrophage Localization (release) of HMGB1 in monocyte
8) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.03

General Comments

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