INT215094

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.84
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Hmgb1) extracellular region (Il6, Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
macrophage 1
Il6 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 100.00 Very High Very High Very High
cytokine 64 56.28 Quite High
Inflammation 16 53.60 Quite High
chemokine 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 104 100.00 Very High Very High Very High
INFLAMMATION 26 100.00 Very High Very High Very High
Disease 6 52.56 Quite High
Endotoxemia 26 39.72 Quite Low
Fever 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Diarrhoea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its beneficial effects in experimental sepsis were partly attributable to: 1) attenuation of systemic accumulation of proinflammatory mediator (e.g., HMGB1) and surrogate markers (e.g., IL-6 and KC) of lethal sepsis; and 2) suppression of HMGB1-mediated inflammatory responses by preventing accumulation of exogenous HMGB1 on macrophage cell surface.
IL-6 Positive_regulation (accumulation) of HMGB1 in macrophage associated with inflammatory response and sepsis
1) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.87 Pain Relevance 0.08
Therefore, we propose that EGCG rescues mice from lethal sepsis partly through inhibiting systemic HMGB1 accumulation, as well as HMGB1-induced release IL-6 and KC.
IL-6 Positive_regulation (accumulation) of HMGB1 associated with sepsis
2) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.97 Pain Relevance 0.09

General Comments

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