INT215095

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Hmgb1) extracellular region (Il6, Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Il6 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 66.72 Quite High
cytokine 32 57.08 Quite High
Inflammation 8 10.72 Low Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 52 99.68 Very High Very High Very High
INFLAMMATION 13 66.36 Quite High
Endotoxemia 13 40.52 Quite Low
Disease 3 9.68 Low Low
Fever 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Diarrhoea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we propose that EGCG rescues mice from lethal sepsis partly through inhibiting systemic HMGB1 accumulation, as well as HMGB1-induced release IL-6 and KC.
Negative_regulation (inhibiting) of IL-6 Positive_regulation (accumulation) of HMGB1 associated with sepsis
1) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.03 Pain Relevance 0.09

General Comments

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