INT215100

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.21
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmgb1, Tlr4) cell morphogenesis (Hmgb1) intracellular (Tlr4)
DNA binding (Hmgb1) signal transduction (Tlr4) extracellular space (Hmgb1)
Anatomy Link Frequency
macrophage 3
Hmgb1 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 194 99.64 Very High Very High Very High
Inflammatory response 34 97.40 Very High Very High Very High
ischemia 20 97.04 Very High Very High Very High
Inflammation 88 95.28 Very High Very High Very High
fibrosis 12 70.04 Quite High
chemokine 22 5.00 Very Low Very Low Very Low
Paracetamol 12 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 117 97.40 Very High Very High Very High
Cv Unclassified Under Development 20 97.04 Very High Very High Very High
Apoptosis 20 93.72 High High
Death 11 93.04 High High
Necrosis 2 92.12 High High
Sepsis 264 90.52 High High
Injury 104 77.08 Quite High
Liver Failure 2 74.72 Quite High
Fibrosis 18 70.04 Quite High
Hypersensitivity 7 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the diverse range of receptors (e.g., TLR2, TLR4, or RAGE) involved in HMGB1 recognition [7], [50], [51], it is intriguing to investigate whether binding of HMGB1 to different receptors leads to combinational clustering of different receptors (such as TLR2 or TLR4) within the lipid rafts [38], [52], [53].
HMGB1 Spec (whether) Binding (binding) of TLR4
1) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.05 Pain Relevance 0.21
Indeed, fluorescence resonance energy transfer (FRET) analysis has demonstrated a close physical interaction between HMGB1 and TLR2 or TLR4 on macrophage cell surface within 5-15 minutes of HMGB1 incubation [47], long before subsequent HMGB1-induced cytokine release.
HMGB1 Binding (interaction) of TLR4 in macrophage associated with cytokine
2) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.30 Pain Relevance 0.26
Indeed, fluorescence resonance energy transfer (FRET) analysis has demonstrated a close physical interaction between HMGB1 and TLR2 or TLR4 on macrophage cell surface within 5-15 minutes of HMGB1 incubation [47], long before subsequent HMGB1-induced cytokine release.
HMGB1 Binding (interaction) of TLR4 in macrophage associated with cytokine
3) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.30 Pain Relevance 0.26
Indeed, fluorescence resonance energy transfer (FRET) analysis has demonstrated a close physical interaction between HMGB1 and TLR2 or TLR4 on macrophage cell surface within 5-15 minutes of HMGB1 incubation [47], long before subsequent HMGB1-induced cytokine release.
HMGB1 Binding (interaction) of TLR4 in macrophage associated with cytokine
4) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.30 Pain Relevance 0.26
Recombinant HMGB1 preparations were tested routinely for LPS content by the chromogenic Limulus amebocyte lysate assay (Endochrome; Charles River), and endotoxin content was below detection limit (<500 pg endotoxin per microgram of rHMGB1).
HMGB1 Binding (content) of LPS
5) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0
It is argued that HMGB1 interacts with TLR4, since TLR4 defective (C3H/HeJ) mice exhibits less damage in the hepatic ischemia-reperfusion model than wt C3H/OuJ mice [20].
HMGB1 Binding (interacts) of TLR4 associated with ischemia
6) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.33 Pain Relevance 0.38
Interactions of HMGB1 with TLR2 and TLR4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS [21].
HMGB1 Binding (Interactions) of TLR4 associated with inflammatory response
7) Confidence 0.12 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.93 Pain Relevance 0.31

General Comments

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