INT215101

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.18
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1, Il6) extracellular region (Hmgb1, Il6) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
macrophage 2
Hmgb1 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 119 94.80 High High
inflammatory response 45 79.84 Quite High
inflammatory 60 73.64 Quite High
chemokine 11 39.20 Quite Low
Inflammatory mediators 15 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
NSAID 5 5.00 Very Low Very Low Very Low
Nicotine 4 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 255 86.48 High High
INFLAMMATION 122 79.48 Quite High
Disease 23 78.84 Quite High
Gynecological Disease 1 62.36 Quite High
Hypersensitivity 3 47.72 Quite Low
Cancer 11 45.60 Quite Low
Endotoxemia 40 5.00 Very Low Very Low Very Low
Infection 21 5.00 Very Low Very Low Very Low
Injury 20 5.00 Very Low Very Low Very Low
Fever 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, EGCG effectively inhibited HMGB1-induced release of IL-6 release, even when it was given 2–4 hours after HMGB1 stimulation (Fig. 7C, and data not shown).
HMGB1 Positive_regulation (induced) of Localization (release) of IL-6
1) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.36 Pain Relevance 0.14
On the other hand, EGCG dose-dependently inhibited cell surface clustering of exogenous HMGB1, and consequently attenuated HMGB1-induced release of proinflammatory mediators (e.g., TNF, IL-6, and NO).
HMGB1 Positive_regulation (induced) of Localization (release) of IL-6
2) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.24
Furthermore, EGCG effectively inhibited HMGB1-induced release of IL-6 release, even when it was given 2–4 hours after HMGB1 stimulation (Fig. 7C, and data not shown).
HMGB1 Positive_regulation (induced) of Localization (release) of IL-6
3) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.36 Pain Relevance 0.12
In addition, EGCG dose-dependently inhibited HMGB1-induced
           release of TNF, IL-6 and nitric oxide in macrophage cultures (Ref. 84). 
HMGB1 Positive_regulation (induced) of Localization (release) of IL-6 in macrophage
4) Confidence 0.04 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.39 Pain Relevance 0.04

General Comments

This test has worked.

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