INT215117

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.66
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Anatomy Link Frequency
eukaryotic cells 1
synovium 1
kidney 1
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 96 98.04 Very High Very High Very High
rheumatoid arthritis 78 96.56 Very High Very High Very High
Inflammation 100 96.00 Very High Very High Very High
Neuropeptide 4 81.36 Quite High
cytokine 41 80.32 Quite High
Pyramidal cell 30 80.24 Quite High
Multiple sclerosis 3 73.68 Quite High
metalloproteinase 128 64.64 Quite High
Arthritis 10 50.96 Quite High
Inflammatory response 7 44.32 Quite Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 132 99.96 Very High Very High Very High
Bacillus Anthracis Infection 13 99.84 Very High Very High Very High
Cancer 161 99.48 Very High Very High Very High
Parkinson's Disease 295 98.04 Very High Very High Very High
Pick Disease Of The Brain 15 97.96 Very High Very High Very High
Gauchers Disease 31 96.96 Very High Very High Very High
Rheumatoid Arthritis 78 96.56 Very High Very High Very High
Cleidocranial Dysplasia 45 96.04 Very High Very High Very High
INFLAMMATION 106 96.00 Very High Very High Very High
Disease 322 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, using cathepsin B deficient APC?
Gene_expression (deficient) of cathepsin associated with familial adenomatous polyposis
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.32 Pain Relevance 0.22
To reveal the cellular source of cathepsin activity, APC?
Gene_expression (source) of cathepsin associated with familial adenomatous polyposis
2) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.47 Pain Relevance 0
The source of cathepsin activity in tumors has been in the past debated, with some reports emphasizing that tumor cells are the major source of this activity.
Gene_expression (source) of cathepsin associated with cancer
3) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.19 Pain Relevance 0.29
-syn degradation [84] and overexpression of Cathepsin D reduces the pathology associated with ?
Gene_expression (overexpression) of Cathepsin
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.35 Pain Relevance 0
Moreover, recent studies have shown that reduced Cathepsin D expression results in ?
Gene_expression (expression) of Cathepsin
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.35 Pain Relevance 0
In addition, rapamycin increased the levels of LC3 and Cathepsin D immunoreactivity (Figure 8O, P).
Gene_expression (levels) of Cathepsin
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.32 Pain Relevance 0
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Gene_expression (levels) of Cathepsin associated with parkinson's disease
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.89 Pain Relevance 0.07
Cathepsin D, the first cathepsin to be identified, is an aspartic proteinase which is ubiquitously expressed in lysosomes of most eukaryotic cells.
Gene_expression (expressed) of cathepsin in eukaryotic cells
8) Confidence 0.13 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.06 Pain Relevance 0
20,000, Cell Signaling) detected with Tyramide Red, and either mTor, Cathepsin D or LC3 detected with fluorescein isothiocyanate (FITC)-conjugated secondary antibodies (1?
Gene_expression (detected) of Cathepsin
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0 Pain Relevance 0
Interestingly, the U-1-7 U3 probe was derived from the lung and cathepsin E was differentially expressed in the lung compared to other tissues, such as kidney [43].
Gene_expression (expressed) of cathepsin E in kidney
10) Confidence 0.11 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.45 Pain Relevance 0.04
There were no meaningful differences between the susceptibilities of either enzyme to cathepsin D digestion.


Gene_expression (digestion) of cathepsin D
11) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
Cathepsins L and F participate in the same process, primarily in tissues or cells that do not express cathepsin S.
Neg (not) Gene_expression (express) of cathepsin
12) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.22 Pain Relevance 0.08
Interestingly, cathepsin B, along with MMP-1 and cathepsin L, has been detected in the synovium soon after onset of symptoms, implying that the potential for joint destruction exists even at very early stages of the disease [45,46].
Gene_expression (detected) of cathepsin in synovium associated with disease
13) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.84 Pain Relevance 0.48
Protective antigen (PA), lethal factor (LF) and LF-E687C (E687C), a mutant form of LF whereby a Glu to Cys substitution at the zinc-binding site results in elimination of enzymatic activity [1], were expressed in Bacillus anthracis (BH445) and purified essentially as described [47], [48].
Gene_expression (expressed) of Protective antigen associated with bacillus anthracis infection
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.19 Pain Relevance 0

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