INT21513

Context Info Confidence 0.05 First Reported 1990 Last Reported 1990 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.32

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) cell-cell signaling (GNRH1)

GNRH1 (Homo sapiens) Lhb (Mus musculus)

Pain Link Frequency Relevance Heat opiate 1 99.60 Endogenous opioid 4 93.48 Dopamine 1 41.28

Disease Link Frequency Relevance Heat Reprotox - General 1 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In basal circumstances beta-endorphin, the most well-known endogenous substance with opiate-like activity, may decrease LH levels by suppressing hypothalamic GnRH.

Negative_regulation (suppressing) of GnRH Spec (may) Negative_regulation (decrease) of LH associated with opiate

1) Confidence 0.05 Published 1990 Journal Int J Sports Med Section Abstract Doc Link 2175732 Disease Relevance 0.14 Pain Relevance 0.32

General Comments

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