INT215148

Context Info Confidence 0.75 First Reported 2007 Last Reported 2011 Negated 2 Speculated 0 Reported most in Body Documents 13 Total Number 14 Disease Relevance 6.57 Pain Relevance 1.02

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)

Anatomy Link Frequency neuronal 4 neurons 2 brain 1 stem cells 1 hippocampus 1 Dcx (Mus musculus)

Pain Link Frequency Relevance Heat Neuropeptide 7 99.02 GABAergic 3 98.88 Hippocampus 187 94.98 Intracerebroventricular 8 83.80 Cannabinoid receptor 12 75.00 lidocaine 6 73.88 antagonist 106 69.84 Inflammation 152 65.84 Central nervous system 58 50.84 Cannabinoid 138 49.72

Disease Link Frequency Relevance Heat Neurodegenerative Disease 864 99.32 Infection 96 98.64 Convulsion 23 94.88 Cytomegalovirus Infection 116 93.28 Viral Infection 26 89.44 Injury 24 88.48 Apoptosis 22 85.24 Death 24 83.40 Anxiety Disorder 46 78.60 INFLAMMATION 180 65.84

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We also show that infection of the developing brain, which is rich in NSCs, results in reduced expression of doublecortin (DCX), a marker that identifies young/immature neurons, while the glial precursor and mature astrocyte marker, glial acidic fibrillary protein (GFAP) expression remained unaltered.

Gene_expression (expression) of doublecortin in brain associated with infection

1) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.88 Pain Relevance 0.03

The migratory neuroblast and GABAergic phenotype of periglomerular cells was reflected in the expression of Dcx [14] (immature neurons) and Gad1 [15] (GAD67 protein in GABAergic interneurons), respectively.

Gene_expression (expression) of Dcx in interneurons associated with gabaergic

2) Confidence 0.59 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2063466 Disease Relevance 0 Pain Relevance 0.10

Finally, we report decreased expression of doublecortin, a marker to identify young neurons, following viral brain infection.

Gene_expression (expression) of doublecortin in neurons associated with infection

3) Confidence 0.58 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.26 Pain Relevance 0

We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells.

Gene_expression (-) of DCX in neuronal

4) Confidence 0.58 Published 2010 Journal Cell Commun Signal Section Abstract Doc Link PMC2898685 Disease Relevance 0.46 Pain Relevance 0.11

We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells.

Gene_expression (expressing) of DCX in neuronal

5) Confidence 0.58 Published 2010 Journal Cell Commun Signal Section Abstract Doc Link PMC2898685 Disease Relevance 0.46 Pain Relevance 0.11

Nestin-GFP-positive, Doublecortin (DCX)-negative cells, but a significant reduction at the level of the type-2b cells (Nestin-GFP-positive, DCX-positive; THC vs.

Neg (negative) Gene_expression (negative) of DCX

6) Confidence 0.58 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.34 Pain Relevance 0

HH3 immunoreactivity (IR), nestin-IR, activated caspase 3-IR, Dcx-IR, CD11b-IR or PECAM-1-IR were revealed using respectively a rabbit anti-HH3 polyclonal antibody (1?

Gene_expression (revealed) of Dcx-IR

7) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.08 Pain Relevance 0.11

In conclusion, deletion of SNAP-25b results in dramatic alterations in neuropeptide levels in the HF, which together with increased levels of BDNF and DCx may provide an environment that promotes neuroprotection/neuroproliferation in response to disrupted synaptic transmission and seizure activity in neo-excised SNAP-25b deficient mutants.

Gene_expression (levels) of DCx associated with convulsion and neuropeptide

8) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0.10

The number of newborn neurons expressing Dcx was decreased in the DG of bigenic-Dox mice (Figures 3D & 3E; t10?

Gene_expression (expressing) of Dcx in neurons

9) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.34 Pain Relevance 0

Nestin-GFP-positive, Doublecortin (DCX)-negative cells, but a significant reduction at the level of the type-2b cells (Nestin-GFP-positive, DCX-positive; THC vs.

Neg (negative) Gene_expression (negative) of Doublecortin

10) Confidence 0.30 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.35 Pain Relevance 0

We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells.

Gene_expression (expressing) of Doublecortin in neuronal

11) Confidence 0.30 Published 2010 Journal Cell Commun Signal Section Abstract Doc Link PMC2898685 Disease Relevance 0.46 Pain Relevance 0.11

We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells.

Gene_expression (-) of Doublecortin in neuronal

12) Confidence 0.30 Published 2010 Journal Cell Commun Signal Section Abstract Doc Link PMC2898685 Disease Relevance 0.46 Pain Relevance 0.11

The increased number of neurons resulted from changes in proliferation of Sox2-positive neural stem cells [21] and nestin-positive precursor cells [22], an effect that led to increased numbers of Dcx expressing neuroblasts and neurogenesis.

Gene_expression (expressing) of Dcx in stem cells associated with neurodegenerative disease

13) Confidence 0.23 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.18

The proliferative zones of the hippocampus contain the following: Sox2-expressing cells, considered to be authentic neural stem cells (NSCs) with multipotent and self-renewing NSC properties [21]; nestin-expressing cells, considered to be neural precursor cells (NPCs) [22]; and doublecortin (Dcx)-expressing cells, considered to be immature migrating neuroblasts [23].

Gene_expression (expressing) of Dcx in hippocampus associated with hippocampus

14) Confidence 0.23 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0 Pain Relevance 0.09

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