INT215149

Context Info Confidence 0.22 First Reported 2007 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0.44 Pain Relevance 0.48

ribosome biogenesis (Sbds) cytoplasm (Sbds) cell proliferation (Sbds) RNA binding (Sbds) nucleolus (Sbds) nucleus (Sbds)

Anatomy Link Frequency bridges 2 Sbds (Mus musculus)

Pain Link Frequency Relevance Heat addiction 39 87.88 cannabis 104 84.24 opiate 1 82.40 alcohol 15 81.96 cINOD 37 5.00 imagery 15 5.00 Neuropeptide 7 5.00 Hippocampus 7 5.00 Cholecystokinin 6 5.00 Eae 6 5.00

Disease Link Frequency Relevance Heat Drug Dependence 5 91.92 Opiate Addiction 1 82.84 Syndrome 2 73.96 Cannabis Dependence 14 66.88 Targeted Disruption 33 62.36 Drug Induced Neurotoxicity 10 50.00 Convulsion 13 19.68 Body Weight 4 12.24 Death 37 5.00 Disease 30 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, in the original publication Gossop et al. [12] explicitly recommend the SDS for research purposes and not for clinical use.

SDS Binding (recommend) of

1) Confidence 0.22 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2636780 Disease Relevance 0.32 Pain Relevance 0.48

Furthermore, any hydration of methylene bridges in RNA-protein complexes will set RNA free due to the preference of SDS to bind to the protein part of methylene crosslinks and the repulsive character of the bulky SDS-protein compound [12].

SDS Binding (bind) of in bridges

2) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2063466 Disease Relevance 0.06 Pain Relevance 0

Furthermore, any hydration of methylene bridges in RNA-protein complexes will set RNA free due to the preference of SDS to bind to the protein part of methylene crosslinks and the repulsive character of the bulky SDS-protein compound [12].

SDS Binding (bind) of in bridges

3) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2063466 Disease Relevance 0.06 Pain Relevance 0

Except for a SDS resistant complex observed at ?

SDS Neg (Except) Binding (complex) of

4) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0

PAGE-SDS and silver staining

SDS Binding (PAGE) of

5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.