INT21516

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.73
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
blood 2
neurons 2
cortex 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 7 99.98 Very High Very High Very High
epidural 3 99.78 Very High Very High Very High
Potency 10 99.66 Very High Very High Very High
cytokine 18 98.88 Very High Very High Very High
nMDA receptor 59 97.40 Very High Very High Very High
Inflammation 36 96.44 Very High Very High Very High
local anesthetic 3 94.72 High High
Paracetamol 12 93.08 High High
halothane 3 91.52 High High
cva 10 85.68 High High
Disease Link Frequency Relevance Heat
Hypoxia 60 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 4 100.00 Very High Very High Very High
Apoptosis 29 99.80 Very High Very High Very High
Death 37 99.40 Very High Very High Very High
Injury 40 99.08 Very High Very High Very High
Hepatotoxicity 7 98.96 Very High Very High Very High
Necrosis 8 97.88 Very High Very High Very High
Stress 42 97.60 Very High Very High Very High
INFLAMMATION 36 96.44 Very High Very High Very High
Body Weight 15 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A good correlation was found between the potency of the drugs to inhibit released LDH induced by 30 microM veratridine in neuronal cultures and their binding affinity for the batrachotoxin binding site of Na+ channels in rat cortex synaptosomal preparation.
Negative_regulation (inhibit) of Positive_regulation (induced) of LDH in cortex associated with potency
1) Confidence 0.43 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.48
Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release.
Negative_regulation (reduction) of Positive_regulation (increase) of LDH
2) Confidence 0.43 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.13 Pain Relevance 0
TFR (20, 40 mg/kg) pretreatment decreased I/R-induced IS/AAR, markedly inhibited the increase of MDA content and the activity of CK and LDH, and also significantly inhibited the decline of NO content and the activity of NOS and SOD in serum.
Negative_regulation (inhibited) of Positive_regulation (increase) of LDH associated with disorders of creatine metabolism
3) Confidence 0.34 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.60 Pain Relevance 0.11
Pretreatment of DA-9601 reduced the elevation of serum ALT, AST, LDH and histopathological changes such as centrilobular necrosis, vacuolar degeneration and inflammatory cell infiltration dose-dependently.
Negative_regulation (reduced) of Positive_regulation (elevation) of LDH associated with necrosis and inflammation
4) Confidence 0.32 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875486 Disease Relevance 0.45 Pain Relevance 0.46
The elevation of the organ damage markers, such as alanine aminotransferase and lactate dehydrogenase, was significantly suppressed in the DA group.
Negative_regulation (suppressed) of Positive_regulation (elevation) of lactate dehydrogenase
5) Confidence 0.29 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2575560 Disease Relevance 0.52 Pain Relevance 0.27
Epidural analgesia inhibited increases in LDH, CPK, glucose and cortisol (P less than 0.05), but not the increase in bilirubin.
Negative_regulation (inhibited) of Positive_regulation (increases) of LDH associated with epidural and analgesia
6) Confidence 0.27 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7324821 Disease Relevance 0 Pain Relevance 0.45
The observed anti-stress activity of l-arginine was due to its anti-oxidative effects, i.e. better maintained anti-oxidants (SOD and catalase), reduced lipid peroxidation (MDA) and a lower increase in blood LDH levels.



Negative_regulation (reduced) of Positive_regulation (increase) of blood LDH in blood associated with stress
7) Confidence 0.24 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062147 Disease Relevance 0.48 Pain Relevance 0
Agmatine prevents hypoxia-induced LDH release and apoptotic death in transformed RGCs (RGC-5 cells).
Negative_regulation (prevents) of Positive_regulation (induced) of LDH release associated with hypoxia, apoptosis and death
8) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.99 Pain Relevance 0
Memantine alone (0.05-2.0 ┬ÁM) concentration-depen-dently attenuated staurosporine-induced caspase-3 activity and lactate dehydrogenase (LDH) release in hippocampal cultured neurons after 7 and 12 days in vitro but had no effect in control cultures.
Negative_regulation (attenuated) of Positive_regulation (induced) of LDH in neurons
9) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.20 Pain Relevance 0.20
RESULTS: Corocalm (48.5 mg/kg and 194.0 mg/kg) significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction.
Negative_regulation (inhibited) of Positive_regulation (increase) of LDH
10) Confidence 0.10 Published 2007 Journal Chin J Integr Med Section Body Doc Link 17898952 Disease Relevance 0.05 Pain Relevance 0
Pre-irradiation with gamma-rays (50 cGy) at 6 hours before addition of 1 mM CHP to the cells significantly suppressed the elevation of LDH activity at 24 hours post-treatment.
Negative_regulation (suppressed) of Positive_regulation (elevation) of LDH
11) Confidence 0.07 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928074 Disease Relevance 0.20 Pain Relevance 0.35
In addition, the eculizumab group had a significant decrease in LDH levels as well as a significant increase in quality of life.
Negative_regulation (decrease) of Positive_regulation (increase) of LDH
12) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.83 Pain Relevance 0.21
However, mild reversible elevations in lactate dehydrogenase, alkaline phosphatase, and uric acid, and decreases in bilirubin, have been reported previously with G-CSF [8, 16].
Negative_regulation (decreases) of Positive_regulation (elevations) of lactate dehydrogenase
13) Confidence 0.01 Published 2010 Journal Ann Hematol Section Body Doc Link PMC2924967 Disease Relevance 0.14 Pain Relevance 0

General Comments

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