INT215162

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.12
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 216 99.84 Very High Very High Very High
Glutamate receptor 3 87.64 High High
agonist 12 64.64 Quite High
antagonist 9 63.60 Quite High
Hyperalgesia 6 60.20 Quite High
allodynia 7 59.52 Quite High
dorsal root ganglion 21 32.16 Quite Low
substance P 8 14.56 Low Low
withdrawal 11 14.40 Low Low
Pain 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 7 60.20 Quite High
Neuropathic Pain 8 59.52 Quite High
Ganglion Cysts 22 50.00 Quite Low
Nociception 24 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Nervous System Injury 15 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Hepatitis 6 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The existence of a proline in the P+1 position in several P2X subunit isoforms (P2X1, P2X2, P2X4) might be one causative factor preventing direct phosphorylation by PKC.
Phosphorylation (phosphorylation) of P2X1 associated with kinase c
1) Confidence 0.43 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.28
Also, PMA treatment did not lead to an increase in the (rather weak) basal phosphorylation of the P2X1 receptor [36].
Phosphorylation (phosphorylation) of P2X1
2) Confidence 0.43 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.42
Phosphorylation of the PKC sites in P2X1 and P2X2 receptor slowed the rate of inactivation of ATP currents [49,50].
Phosphorylation (Phosphorylation) of P2X1
3) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.12 Pain Relevance 0.24
Although the pharmacological data are basically consistent with PKC-mediated receptor phosphorylation being involved, mutant P2X1 receptors with a disrupted N-terminal PKC site (T18V) still showed PMA-mediated and mGluR1?
Phosphorylation (phosphorylation) of P2X1 associated with kinase c
4) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.41

General Comments

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