INT215169

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2, P2rx2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 1
Ptger2 (Rattus norvegicus)
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 83.16 Quite High
Root ganglion neuron 2 81.00 Quite High
dorsal root ganglion 42 58.56 Quite High
allodynia 14 43.68 Quite Low
Hyperalgesia 12 42.56 Quite Low
antagonist 18 31.60 Quite Low
withdrawal 22 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 18 91.84 High High
INFLAMMATION 14 83.16 Quite High
Ganglion Cysts 44 75.00 Quite High
Neuropathic Pain 16 43.68 Quite Low
Hyperalgesia 14 42.56 Quite Low
Nervous System Injury 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 had no effects on P2X2/3 receptor-mediated responses, but significantly potentiated fast-inactivating ATP currents mediated by homomeric P2X3 receptors.
PGE2 Neg (no) Regulation (effects) of P2X2 in PGE2
1) Confidence 0.19 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.25 Pain Relevance 0.08
These results suggest that PGE2 acts on the homomeric P2X3 receptors, but not on the heteromeric P2X2/3 receptors.


PGE2 Neg (not) Regulation (acts) of P2X2
2) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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