INT215171

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Ptger2 (Rattus norvegicus)
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 42 90.00 High High
substance P 4 89.52 High High
antagonist 18 69.20 Quite High
agonist 12 68.60 Quite High
Pain 6 46.64 Quite Low
Inflammation 14 16.40 Low Low
withdrawal 22 5.00 Very Low Very Low Very Low
allodynia 14 5.00 Very Low Very Low Very Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 90.00 High High
Pain 6 46.64 Quite Low
Nervous System Injury 12 40.88 Quite Low
Injury 2 31.44 Quite Low
Nociception 18 17.80 Low Low
INFLAMMATION 14 16.40 Low Low
Neuropathic Pain 16 5.00 Very Low Very Low Very Low
Hyperalgesia 14 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is the only EP3 variant coupled to Gs to produce cAMP [55], we suggest that PGE2 acts on EP3C to potentiate the response of P2X3 currents.
PGE2 Regulation (response) of P2X3
1) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.40 Pain Relevance 0.38
These results suggest that PGE2 acts on the homomeric P2X3 receptors, but not on the heteromeric P2X2/3 receptors.


PGE2 Neg (not) Regulation (acts) of homomeric P2X3
2) Confidence 0.12 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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