INT215183

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.78
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC) cell adhesion (MUC5AC)
Anatomy Link Frequency
pancreas 1
MUC5AC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 79 98.32 Very High Very High Very High
Inflammation 122 90.40 High High
dexamethasone 27 86.12 High High
imagery 3 84.28 Quite High
agonist 30 70.32 Quite High
gABA 118 5.00 Very Low Very Low Very Low
GABAergic 92 5.00 Very Low Very Low Very Low
chemokine 29 5.00 Very Low Very Low Very Low
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
Nicotine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholesteatoma 48 97.28 Very High Very High Very High
Cancer 31 94.80 High High
INFLAMMATION 156 90.40 High High
Nicotine Addiction 136 86.80 High High
Adenocarcinoma 14 86.68 High High
Mucinous Adenocarcinoma 1 80.88 Quite High
Otitis Media 134 76.08 Quite High
Asthma 50 72.32 Quite High
Carcinoma 7 71.56 Quite High
Otitis Media With Effusion 92 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression construct blocked CRA induction of Gob-5 and Muc5-ac.


Positive_regulation (induction) of Muc5-ac
1) Confidence 0.45 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2231357 Disease Relevance 0.38 Pain Relevance 0.37
Based on the microarray data, we defined "high GAD67" or "high MUC5AC" gene expression as ?
Positive_regulation (high) of MUC5AC
2) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.22 Pain Relevance 0.04
Based on the microarray data, we defined "high GAD67" or "high MUC5AC" gene expression as ?
Positive_regulation (high) of MUC5AC
3) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.22 Pain Relevance 0.04
-Smad signaling, however, led to down-regulation of p38 by including MAPK phosphatase-1 (MKP-1), thereby acting as a negative regulator for MUC5AC induction (248).


Positive_regulation (induction) of MUC5AC
4) Confidence 0.14 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.14 Pain Relevance 0.15
Fig. 1Histological subtypes of intraductal papillary-mucinous neoplasms of the pancreas and their usual mucin pattern. a, b IPMN of the intestinal type positive for MUC2; c, d IPMN of the pancreatobiliary type positive for MUC1; e, f IPMN of the oncocytic type showing scattered positivity for MUC2; g, h IPMN of the gastric type, positive for MUC5
Positive_regulation (positive) of MUC5 in pancreas associated with cancer
5) Confidence 0.12 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2063564 Disease Relevance 0.82 Pain Relevance 0

General Comments

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