INT215185

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.62
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nnat)
Anatomy Link Frequency
neuronal 1
neurons 1
dorsal root ganglions 1
Nnat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 105 99.84 Very High Very High Very High
Sciatic nerve 85 99.34 Very High Very High Very High
Pain 15 99.16 Very High Very High Very High
unmyelinated 30 97.32 Very High Very High Very High
c fibre 50 96.80 Very High Very High Very High
Peripheral nerve injury 30 94.72 High High
Neuropathic pain 75 92.64 High High
Hyperalgesia 30 92.40 High High
Central nervous system 5 80.72 Quite High
addiction 3 73.16 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 150 99.84 Very High Very High Very High
Pain 45 99.16 Very High Very High Very High
Nervous System Injury 40 94.72 High High
Neuropathic Pain 95 92.64 High High
Hyperalgesia 30 92.40 High High
Cancer 42 83.04 Quite High
Stress 15 80.04 Quite High
Pressure And Volume Under Development 33 73.80 Quite High
Aging 5 73.28 Quite High
Disease 9 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, according to the immunohistochemical results, it showed that after the sciatic nerve was axotomized, the subcellular localization of Nnat in DRG was confirmed by peripherin-positive neuronal cells, where the expression of Nnat was also increased.
Localization (localization) of Nnat in neuronal associated with dorsal root ganglion and sciatic nerve
1) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.83 Pain Relevance 0.76
To examine the expression of Nnat in large versus small DRG neurons, we co-localized Nnat by immunofluorescence staining with peripherin, a marker of small unmyelinated C-fiber and thinly myelinated A-?
Localization (localized) of Nnat in neurons associated with c fibre, dorsal root ganglion and unmyelinated
2) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.54 Pain Relevance 0.51
Western blotting, immunohistochemistry, and the Randall and Selitto test were used to study the protein content, and subcellular localization of Nnat in correlation with pain-related animal behavior.


Localization (localization) of Nnat associated with pain
3) Confidence 0.61 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2894761 Disease Relevance 0.64 Pain Relevance 0.60
forms of Nnat was the presence in the ?
Localization (forms) of Nnat
4) Confidence 0.61 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.13 Pain Relevance 0.18
fiber in adult dorsal root ganglions (DRGs) were the principal sub-population of primary afferent neurons with distributed Nnat.
Localization (distributed) of Nnat in dorsal root ganglions associated with ganglion cysts
5) Confidence 0.61 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2894761 Disease Relevance 0.71 Pain Relevance 0.63
However, considerable foaming made liposome preparation difficult; the foaming was likely related to the presence of PEG-DSPE micelles (24).
Localization (presence) of PEG
6) Confidence 0.13 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063565 Disease Relevance 0 Pain Relevance 0
The triggered release of adsorbed PEG-b-polycation polymers from pH-dependent liposomes may protect the drug carrier from immune recognition during circulation (pH 7.4) and allow subsequent intracellular delivery of siRNA within the endosome.
Localization (release) of PEG
7) Confidence 0.01 Published 2010 Journal J Biol Eng Section Body Doc Link PMC3002303 Disease Relevance 0.26 Pain Relevance 0.03
The polycation block electrostatically anchored the PEG polymer to the liposome surface at pH 7.4, but released the polymer at pH 5.5 due to electrostatic repulsion between the cationic polymer and cationic liposome surface.
Localization (released) of PEG
8) Confidence 0.01 Published 2010 Journal J Biol Eng Section Body Doc Link PMC3002303 Disease Relevance 0.30 Pain Relevance 0.04
Their liposome formulation, composed of 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), hydrogenated soy sn-glycero-3-phosphocholine (HSPC), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol 2000 (DSPE-PEG-2000), was optimized to rapidly release the drug under mild hyperthermic temperatures (39°C to 40°C).
Localization (release) of PEG
9) Confidence 0.01 Published 2010 Journal J Biol Eng Section Body Doc Link PMC3002303 Disease Relevance 0.23 Pain Relevance 0

General Comments

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