INT21520

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Context Info
Confidence 0.22
First Reported 1987
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.40
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Pomc) extracellular region (Crh, Pomc) cytoplasm (Crh, Pomc)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 2
Crh (Rattus norvegicus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 14 98.38 Very High Very High Very High
opiate 8 90.80 High High
Morphine 14 90.44 High High
withdrawal 4 77.52 Quite High
antagonist 2 67.28 Quite High
palliative 1 59.20 Quite High
Clonidine 2 50.96 Quite High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 94.16 High High
Disease 2 75.00 Quite High
Syndrome 1 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tolerance does not occur at the pituitary or adrenal levels after these paradigms because ACTH and CS responses to exogenous corticotropin-releasing factor and ACTH, respectively, were not attenuated.
exogenous corticotropin-releasing factor Regulation (responses) of ACTH in pituitary associated with tolerance
1) Confidence 0.22 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175800 Disease Relevance 0.09 Pain Relevance 1.20
Tolerance does not occur at the pituitary or adrenal levels after these paradigms because ACTH and CS responses to exogenous corticotropin-releasing factor and ACTH, respectively, were not attenuated.
exogenous corticotropin-releasing factor Regulation (responses) of ACTH in pituitary associated with tolerance
2) Confidence 0.22 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175800 Disease Relevance 0.09 Pain Relevance 1.20
Basal ACTH levels were increased in four patients and ACTH response to oCRH was enhanced in all, compared to pretreatment.
oCRH Regulation (response) of ACTH
3) Confidence 0.00 Published 1987 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2830063 Disease Relevance 0.21 Pain Relevance 0.06

General Comments

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