INT215202

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.50
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
cleavage 3
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 135 100.00 Very High Very High Very High
Inflammation 82 98.48 Very High Very High Very High
metalloproteinase 30 67.92 Quite High
Inflammatory response 29 56.48 Quite High
cytokine 62 20.64 Low Low
sodium channel 1 5.20 Low Low
chemokine 13 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 81 100.00 Very High Very High Very High
INFLAMMATION 113 98.48 Very High Very High Very High
Pulmonary Fibrosis 63 88.88 High High
Targeted Disruption 57 86.96 High High
Body Weight 3 80.84 Quite High
Injury 33 65.32 Quite High
Cancer 26 64.60 Quite High
Overactive Bladder 18 45.72 Quite Low
Disease 19 44.04 Quite Low
Lung Injury 6 23.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recruited neutrophils release MMP-9, which has a protective role in bleomycin-induced fibrosis [17] through cleavage of potential profibrotic mediators such as insulin-like growth factor binding protein-3 (IGFBP3).
Localization (Recruited) of IGFBP3 in cleavage associated with fibrosis
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.79 Pain Relevance 0.31
Recruited neutrophils release MMP-9, which has a protective role in bleomycin-induced fibrosis [17] through cleavage of potential profibrotic mediators such as insulin-like growth factor binding protein-3 (IGFBP3).
Localization (release) of IGFBP3 in cleavage associated with fibrosis
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.78 Pain Relevance 0.30
Recruited neutrophils release MMP-9, which has a protective role in bleomycin-induced fibrosis [17] through cleavage of potential profibrotic mediators such as insulin-like growth factor binding protein-3 (IGFBP3).
Localization (Recruited) of factor binding protein-3 in cleavage associated with fibrosis
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.79 Pain Relevance 0.30
With the exception of SEMA5A, FVBP1, IGFBP3, and SELE, these results indicate that chronic treatment with BCG and to a lesser extent acute BCG induced up-regulation of the following genes as was predicted by the mRNA-level analysis: ARL6, CSK, DNAJC5, FAF1, GBP2, GZMA, HLA-DRB1, IL17b, INDO, MAP3K8, SMAD6, TFEB, VCAM1, and WISP2.


Localization (exception) of IGFBP3
4) Confidence 0.41 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.06 Pain Relevance 0
To investigate the biological activity of released hGH serum levels of IGF-1 and IGFBP-3, two biomarkers for hGH, were also monitored.


Localization (released) of IGFBP-3
5) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0.08 Pain Relevance 0

General Comments

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