INT215223

Context Info Confidence 0.45 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.73 Pain Relevance 0

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a) GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)

Anatomy Link Frequency melanocytes 3 hematopoietic cells 1 Rab27a (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory mediators 4 36.96 Serotonin 12 30.92 imagery 8 5.00 cytokine 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Immunodeficiency 2 86.48 Piebaldism 2 83.80 Syndrome 4 81.72 Targeted Disruption 98 56.16 Asthma 4 44.24 Disease 4 43.60 Hypersensitivity 12 43.24 INFLAMMATION 4 36.56 Anaphylaxis 20 5.00 Sprains And Strains 6 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present evidence thus suggests that Rab27a acts as a positive regulator of regulated secretion in either conventional Golgi-derived granules in exocrine and endocrine cells, or lysosome-related organelles in hematopoietic cells and melanocytes (19,21,24).

Regulation (regulated) of Localization (secretion) of Rab27a in melanocytes

1) Confidence 0.45 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.36 Pain Relevance 0

The present evidence thus suggests that Rab27a acts as a positive regulator of regulated secretion in either conventional Golgi-derived granules in exocrine and endocrine cells, or lysosome-related organelles in hematopoietic cells and melanocytes (19,21,24).

Regulation (regulated) of in hematopoietic cells Localization (secretion) of Rab27a in melanocytes

2) Confidence 0.15 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.36 Pain Relevance 0

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