INT215224

Context Info Confidence 0.27 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.03

Golgi apparatus (Rab27b) plasma membrane (Rab27b) GTPase activity (Rab27b) cytoplasm (Rab27b)

Anatomy Link Frequency mast cell 1 Rab27b (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 6 53.52 imagery 4 5.00 Inflammatory mediators 2 5.00 cytokine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 6 99.80 Disease 2 99.44 Asthma 2 98.72 Targeted Disruption 49 97.96 Leukemia 1 76.84 Syndrome 2 9.84 Anaphylaxis 10 5.00 Sprains And Strains 3 5.00 INFLAMMATION 2 5.00 Exsanguination 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The identification of severely reduced mast cell responses in vivo in the Rab27b KO mouse is the first report that Rab27b contributes to allergic responses in mammals and suggests that Rab27b may be a future drug target for allergic diseases, such as asthma.

Regulation (target) of Rab27b in mast cell associated with asthma, targeted disruption, hypersensitivity and disease

1) Confidence 0.27 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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