INT215228

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rab27b) plasma membrane (Rab27b) GTPase activity (Rab27b)
cytoplasm (Rab27b)
Anatomy Link Frequency
melanocytes 2
mast cell 2
Rab27b (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 12 56.44 Quite High
imagery 8 37.76 Quite Low
cytokine 2 32.32 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 98 99.72 Very High Very High Very High
Syndrome 4 99.08 Very High Very High Very High
Anaphylaxis 20 93.16 High High
Hypersensitivity 12 64.12 Quite High
Sprains And Strains 6 6.68 Low Low
Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Asthma 4 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Edema 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results above suggested that both Rab27a and Rab27b expression was required for normal mast cell function, presumably in the control of regulated secretion.
Positive_regulation (required) of Gene_expression (expression) of Rab27b in mast cell
1) Confidence 0.69 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.79 Pain Relevance 0.03
The partial redundancy of the Rab27 isoforms was expected given our previous studies on the pathogenesis of Griscelli syndrome where we showed that transgenic heterologous expression of Rab27b in melanocytes could compensate for melanosome clustering and coat color dilution in Rab27a KO (ash) mice (32).
Positive_regulation (compensate) of Gene_expression (expression) of Rab27b in melanocytes associated with targeted disruption and syndrome
2) Confidence 0.50 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.56 Pain Relevance 0

General Comments

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